TY - JOUR
T1 - Diagnostic biomarkers for obsessive-compulsive disorder
T2 - A reasonable quest or ignis fatuus?
AU - Fullana, Miquel A.
AU - Abramovitch, Amitai
AU - Via, Esther
AU - López-Sola, Clara
AU - Goldberg, Ximena
AU - Reina, Nuria
AU - Fortea, Lydia
AU - Solanes, Aleix
AU - Buckley, Matthew J.
AU - Ramella-Cravaro, Valentina
AU - Carvalho, André F.
AU - Tortella-Feliu, Miquel
AU - Vieta, Eduard
AU - Soriano-Mas, Carles
AU - Lázaro, Luisa
AU - Stein, Dan J.
AU - Fernández de la Cruz, Lorena
AU - Mataix-Cols, David
AU - Radua, Joaquim
N1 - Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2020/11
Y1 - 2020/11
N2 - Obsessive-compulsive disorder (OCD) has been associated with a wide range of biological and neurocognitive findings, which could assist in the search for biomarkers. We conducted an umbrella review of systematic reviews and meta-analyses to assess and grade the strength of the evidence of the association between OCD and several potential diagnostic biomarkers while controlling for several potential biases. Twenty-four systematic reviews and meta-analyses were included, comprising 352 individual studies, more than 10,000 individuals with OCD, and covering 73 potential biomarkers. OCD was significantly associated with several neurocognitive biomarkers, with varying degrees of evidence, ranging from weak to convincing. A number of biochemical, neurophysiological, and neuroimaging biomarkers also showed statistically significant, albeit weak, associations with OCD. Analyses in unmedicated samples (123 studies) weakened the strength of the evidence for most biomarkers or rendered them non-significant. None of the biomarkers seem to have sufficient sensitivity and specificity to become a diagnostic biomarker. A more promising avenue for future biomarker research in OCD might be the prediction of clinical outcomes rather than diagnosis.
AB - Obsessive-compulsive disorder (OCD) has been associated with a wide range of biological and neurocognitive findings, which could assist in the search for biomarkers. We conducted an umbrella review of systematic reviews and meta-analyses to assess and grade the strength of the evidence of the association between OCD and several potential diagnostic biomarkers while controlling for several potential biases. Twenty-four systematic reviews and meta-analyses were included, comprising 352 individual studies, more than 10,000 individuals with OCD, and covering 73 potential biomarkers. OCD was significantly associated with several neurocognitive biomarkers, with varying degrees of evidence, ranging from weak to convincing. A number of biochemical, neurophysiological, and neuroimaging biomarkers also showed statistically significant, albeit weak, associations with OCD. Analyses in unmedicated samples (123 studies) weakened the strength of the evidence for most biomarkers or rendered them non-significant. None of the biomarkers seem to have sufficient sensitivity and specificity to become a diagnostic biomarker. A more promising avenue for future biomarker research in OCD might be the prediction of clinical outcomes rather than diagnosis.
KW - Biomarker
KW - Meta-analysis
KW - Obsessive-compulsive disorder
KW - Umbrella review
UR - http://www.scopus.com/inward/record.url?scp=85090160209&partnerID=8YFLogxK
U2 - 10.1016/j.neubiorev.2020.08.008
DO - 10.1016/j.neubiorev.2020.08.008
M3 - Review article
C2 - 32866526
AN - SCOPUS:85090160209
SN - 0149-7634
VL - 118
SP - 504
EP - 513
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
ER -