A probable case of cryptococcal uveitis is reported. The frequent occurrence of meningeal involvement is indicated by abnormal cerebrospinal fluid findings and cultural isolation of Cryptococcus neuformans in all patients in which these studies have been presented. The value of cultivating for wall-deficient microbial variants by using hypertonic media had been previously demonstrated in candidiasis and is further supported by the recovery of aberrant forms of C. neoformans in the cerebrospinal fluid of this patient. The usefulness of the latex slide agglutination test for detecting cryptococcal antigen is again emphasized. Since chemotherapy with amphotericin B is available for the therapy of infections due to this organism, it is important to consider it in the evaluation of patients with uveitis of undetermined etiology, especially when corticosteroid therapy is ineffective.