Diagnosis and treatment options for sequelae following radiation treatment of brain tumors

Swapnil Mehta, Aatman Shah, Henry Jung

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

Radiation serves an important role in the treatment of metastatic and primary brain tumors. Radiation carries a risk of post radiation treatment effects, such as pseudoprogression and radiation necrosis. The ability to differentiate between radiation necrosis, pseudoprogression, and tumor recurrence remains a diagnostic conundrum with varying treatment options. In this review, we will discuss the pathophysiology, diagnostic imaging modalities, and treatments of these post-radiation treatment effects. We focus on the latest developments in magnetic resonance imaging (MRI) modalities including imaging biomarkers and the newest therapeutics such as VEGF inhibitors, Hyperbaric Oxygen Therapy, sensitized cytotoxic T cells, and Laser Interstitial Thermal Therapy (LITT).

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalClinical Neurology and Neurosurgery
Volume163
DOIs
StatePublished - Dec 2017
Externally publishedYes

Keywords

  • APT-MRI
  • Biomarkers
  • LITT
  • Radiation necrosis
  • Radiosurgery
  • VEGF

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