Diagnosis and treatment options for sequelae following radiation treatment of brain tumors

Swapnil Mehta; Aatman Shah; Henry Jung

doi:10.1016/j.clineuro.2017.09.010

Diagnosis and treatment options for sequelae following radiation treatment of brain tumors

Swapnil Mehta, Aatman Shah, Henry Jung

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

Radiation serves an important role in the treatment of metastatic and primary brain tumors. Radiation carries a risk of post radiation treatment effects, such as pseudoprogression and radiation necrosis. The ability to differentiate between radiation necrosis, pseudoprogression, and tumor recurrence remains a diagnostic conundrum with varying treatment options. In this review, we will discuss the pathophysiology, diagnostic imaging modalities, and treatments of these post-radiation treatment effects. We focus on the latest developments in magnetic resonance imaging (MRI) modalities including imaging biomarkers and the newest therapeutics such as VEGF inhibitors, Hyperbaric Oxygen Therapy, sensitized cytotoxic T cells, and Laser Interstitial Thermal Therapy (LITT).

Original language	English
Pages (from-to)	1-8
Number of pages	8
Journal	Clinical Neurology and Neurosurgery
Volume	163
DOIs	https://doi.org/10.1016/j.clineuro.2017.09.010
State	Published - Dec 2017
Externally published	Yes

Keywords

APT-MRI
Biomarkers
LITT
Radiation necrosis
Radiosurgery
VEGF

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title = "Diagnosis and treatment options for sequelae following radiation treatment of brain tumors",

abstract = "Radiation serves an important role in the treatment of metastatic and primary brain tumors. Radiation carries a risk of post radiation treatment effects, such as pseudoprogression and radiation necrosis. The ability to differentiate between radiation necrosis, pseudoprogression, and tumor recurrence remains a diagnostic conundrum with varying treatment options. In this review, we will discuss the pathophysiology, diagnostic imaging modalities, and treatments of these post-radiation treatment effects. We focus on the latest developments in magnetic resonance imaging (MRI) modalities including imaging biomarkers and the newest therapeutics such as VEGF inhibitors, Hyperbaric Oxygen Therapy, sensitized cytotoxic T cells, and Laser Interstitial Thermal Therapy (LITT).",

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T1 - Diagnosis and treatment options for sequelae following radiation treatment of brain tumors

AU - Mehta, Swapnil

AU - Shah, Aatman

AU - Jung, Henry

PY - 2017/12

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N2 - Radiation serves an important role in the treatment of metastatic and primary brain tumors. Radiation carries a risk of post radiation treatment effects, such as pseudoprogression and radiation necrosis. The ability to differentiate between radiation necrosis, pseudoprogression, and tumor recurrence remains a diagnostic conundrum with varying treatment options. In this review, we will discuss the pathophysiology, diagnostic imaging modalities, and treatments of these post-radiation treatment effects. We focus on the latest developments in magnetic resonance imaging (MRI) modalities including imaging biomarkers and the newest therapeutics such as VEGF inhibitors, Hyperbaric Oxygen Therapy, sensitized cytotoxic T cells, and Laser Interstitial Thermal Therapy (LITT).

AB - Radiation serves an important role in the treatment of metastatic and primary brain tumors. Radiation carries a risk of post radiation treatment effects, such as pseudoprogression and radiation necrosis. The ability to differentiate between radiation necrosis, pseudoprogression, and tumor recurrence remains a diagnostic conundrum with varying treatment options. In this review, we will discuss the pathophysiology, diagnostic imaging modalities, and treatments of these post-radiation treatment effects. We focus on the latest developments in magnetic resonance imaging (MRI) modalities including imaging biomarkers and the newest therapeutics such as VEGF inhibitors, Hyperbaric Oxygen Therapy, sensitized cytotoxic T cells, and Laser Interstitial Thermal Therapy (LITT).

KW - APT-MRI

KW - Biomarkers

KW - LITT

KW - Radiation necrosis

KW - Radiosurgery

KW - VEGF

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DO - 10.1016/j.clineuro.2017.09.010

M3 - Review article

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VL - 163

SP - 1

EP - 8

JO - Clinical Neurology and Neurosurgery

JF - Clinical Neurology and Neurosurgery

ER -

Diagnosis and treatment options for sequelae following radiation treatment of brain tumors

Abstract

Keywords

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