40 Scopus citations


Diabetes is a worldwide health problem that has been increasingly associated with various types of cancers. Epidemiologic studies have shown an increased risk of cancer as well as a higher mortality rate in patients with type 2 diabetes (T2D). The biologic mechanisms driving the link between T2D and cancer are not well understood. In this review, various proposed mechanisms are addressed to explain the relationship between T2D and cancer. Understanding the precise mechanisms that link T2D, obesity, and the metabolic syndrome with cancer will aid in developing treatments that will reduce mortality in individuals with T2D and cancer.

Original languageEnglish
Pages (from-to)167-185
Number of pages19
JournalEndocrinology and Metabolism Clinics of North America
Issue number1
StatePublished - Mar 2014


  • Cancer
  • Diabetes mellitus
  • Hyperglycemia
  • Hyperinsulinemia
  • Inflammation
  • Metabolic syndrome
  • Obesity


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