@inbook{df15c14d8a64449ba56232bd328c274d,
title = "Dextran sulfate sodium (DSS)-induced acute colitis in the rat",
abstract = "Infl ammatory bowel diseases (IBDs) are complex multifactorial disease thought to result from inappropriate immune responses to the gut microbiota, in genetically susceptible individuals, under the infl uence of environmental factors. Among the different animal models developed to help in understanding IBDs pathophysiological mechanisms as well as to achieve pharmacological preclinical studies, the dextran sulphate sodium (DSS)-induced colitis model is the most widely used because of its simplicity, cost-effectiveness, and similarity with human IBDs. This section provides with a detailed protocol that we validated in our laboratory to perform DSS-induced acute colitis in the Sprague-Dawley (SPD) rat.",
keywords = "Animal models, Colitis, Crohn{\textquoteright}s disease, Dextran sodium sulfate, Infl ammatory bowel disease, Rats, Ulcerative colitis",
author = "Martin, \{J{\'e}r{\^o}me C.\} and Ga{\"e}lle B{\'e}riou and R{\'e}gis Josien",
note = "Publisher Copyright: {\textcopyright} Springer Science+Business Media New York 2016.",
year = "2016",
doi = "10.1007/978-1-4939-3139-2\_12",
language = "English",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "197--203",
booktitle = "Methods in Molecular Biology",
}