Dexmedetomidine controls twitch-convulsive syndrome in the course of uremic encephalopathy

Koichi Nomoto, Corey Scurlock, David Bronster

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


An 85 year old man with a history of chronic renal insufficiency was admitted to the cardiothoracic intensive care unit after aortic valve replacement. His postoperative course was marked by acute oliguric renal failure for high blood urea nitrogen (BUN) and acute hyperactive delirium. At this time he also developed tremors with muscle twitching; he received no other form of sedatives. A neurology consult made the diagnosis of twitch-convulsive syndrome associated with uremic encephalopathy. While the patient was receiving the dexmedetomidine infusion, the signs of the twitch-convulsive syndrome, particularly the twitching and tremors, disappeared. Within 30 minutes of the end of the dexmedetomidine infusion, symptoms of the twitch-convulsive syndrome returned, manifesting as acute tremulousness. After several dialysis treatments, his BUN decreased and the dexmedetomidine was weaned, without return of the symptoms of twitch-convulsive syndrome.

Original languageEnglish
Pages (from-to)646-648
Number of pages3
JournalJournal of Clinical Anesthesia
Issue number8
StatePublished - Dec 2011


  • Chronic renal insufficiency
  • Dexmedetomidine
  • Twitch-convulsive syndrome
  • Uremic encephalopathy


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