Devices and cardiac remodeling

The impact that left ventricular assist devices (LVADs) have on the remodeling process has been the subject of numerous studies. The impact of these devices has been investigated with regard to chamber geometry, calcium regulation, the extracellular matrix, and cardiac myocyte properties. Reverse remodeling that is seen in these patients stems from the LVAD unloading the ventricle. Passive ventricular constraint devices are relatively new. The manner in which they function differs from LVADs. Also, passive ventricular constraint devices are intended for a different subpopulation of heart failure patients; however, like LVADs, they appear to reverse the remodeling process and may help prevent certain patients from ever requiring an LVAD or transplantation at a later date.