Developmental trauma is associated with behavioral hyperarousal, altered HPA axis activity, and decreased hippocampal neurotrophin expression in the adult rat

Joachim D.K. Uys; Lelanie Marais; Jacqueline Faure; Desiree Prevoo; Pieter Swart; Abdul H. Mohammed; Dan J. Stein; Willie M.U. Daniels

doi:10.1196/annals.1364.060

Developmental trauma is associated with behavioral hyperarousal, altered HPA axis activity, and decreased hippocampal neurotrophin expression in the adult rat

Joachim D.K. Uys
, Lelanie Marais
, Jacqueline Faure
, Desiree Prevoo
, Pieter Swart
, Abdul H. Mohammed
, Dan J. Stein
, Willie M.U. Daniels

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Effects of early-life trauma on adult behavioral responses, corticosterone (CORT) concentration, and levels of nerve growth factor (NGF), brain-derived neutrophic factor (BDNF), and neurotrophin-3 (NT-3) in hippocampus and frontal cortex were investigated. Traumatized animals showed an increase in rearing in both the elevated plus maze and open field after adult restress, higher basal levels of CORT, lower levels of BDNF in dorsal hippocampus, and lower levels of NT-3 in dorsal and ventral hippocampus. Trauma-related behavioral hyperarousal and altered hypothalamic-pituitary-adrenal (HPA) axis activity may be mediated by decreases in hippocampal neurotrophin expression.

Original language	English
Pages (from-to)	542-546
Number of pages	5
Journal	Annals of the New York Academy of Sciences
Volume	1071
DOIs	https://doi.org/10.1196/annals.1364.060
State	Published - Jul 2006
Externally published	Yes

Keywords

Adrenal glands
BDNF
Dorsal hippocampus
Early-life stress
NGF
NT-3
Time-dependent sensitization
Ventral hippocampus

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10.1196/annals.1364.060

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Uys, J. D. K., Marais, L., Faure, J., Prevoo, D., Swart, P., Mohammed, A. H., Stein, D. J., & Daniels, W. M. U. (2006). Developmental trauma is associated with behavioral hyperarousal, altered HPA axis activity, and decreased hippocampal neurotrophin expression in the adult rat. Annals of the New York Academy of Sciences, 1071, 542-546. https://doi.org/10.1196/annals.1364.060

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title = "Developmental trauma is associated with behavioral hyperarousal, altered HPA axis activity, and decreased hippocampal neurotrophin expression in the adult rat",

abstract = "Effects of early-life trauma on adult behavioral responses, corticosterone (CORT) concentration, and levels of nerve growth factor (NGF), brain-derived neutrophic factor (BDNF), and neurotrophin-3 (NT-3) in hippocampus and frontal cortex were investigated. Traumatized animals showed an increase in rearing in both the elevated plus maze and open field after adult restress, higher basal levels of CORT, lower levels of BDNF in dorsal hippocampus, and lower levels of NT-3 in dorsal and ventral hippocampus. Trauma-related behavioral hyperarousal and altered hypothalamic-pituitary-adrenal (HPA) axis activity may be mediated by decreases in hippocampal neurotrophin expression.",

keywords = "Adrenal glands, BDNF, Dorsal hippocampus, Early-life stress, NGF, NT-3, Time-dependent sensitization, Ventral hippocampus",

author = "Uys, \{Joachim D.K.\} and Lelanie Marais and Jacqueline Faure and Desiree Prevoo and Pieter Swart and Mohammed, \{Abdul H.\} and Stein, \{Dan J.\} and Daniels, \{Willie M.U.\}",

year = "2006",

month = jul,

doi = "10.1196/annals.1364.060",

language = "English",

volume = "1071",

pages = "542--546",

journal = "Annals of the New York Academy of Sciences",

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Developmental trauma is associated with behavioral hyperarousal, altered HPA axis activity, and decreased hippocampal neurotrophin expression in the adult rat. / Uys, Joachim D.K.; Marais, Lelanie; Faure, Jacqueline et al.
In: Annals of the New York Academy of Sciences, Vol. 1071, 07.2006, p. 542-546.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Developmental trauma is associated with behavioral hyperarousal, altered HPA axis activity, and decreased hippocampal neurotrophin expression in the adult rat

AU - Uys, Joachim D.K.

AU - Marais, Lelanie

AU - Faure, Jacqueline

AU - Prevoo, Desiree

AU - Swart, Pieter

AU - Mohammed, Abdul H.

AU - Stein, Dan J.

AU - Daniels, Willie M.U.

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N2 - Effects of early-life trauma on adult behavioral responses, corticosterone (CORT) concentration, and levels of nerve growth factor (NGF), brain-derived neutrophic factor (BDNF), and neurotrophin-3 (NT-3) in hippocampus and frontal cortex were investigated. Traumatized animals showed an increase in rearing in both the elevated plus maze and open field after adult restress, higher basal levels of CORT, lower levels of BDNF in dorsal hippocampus, and lower levels of NT-3 in dorsal and ventral hippocampus. Trauma-related behavioral hyperarousal and altered hypothalamic-pituitary-adrenal (HPA) axis activity may be mediated by decreases in hippocampal neurotrophin expression.

AB - Effects of early-life trauma on adult behavioral responses, corticosterone (CORT) concentration, and levels of nerve growth factor (NGF), brain-derived neutrophic factor (BDNF), and neurotrophin-3 (NT-3) in hippocampus and frontal cortex were investigated. Traumatized animals showed an increase in rearing in both the elevated plus maze and open field after adult restress, higher basal levels of CORT, lower levels of BDNF in dorsal hippocampus, and lower levels of NT-3 in dorsal and ventral hippocampus. Trauma-related behavioral hyperarousal and altered hypothalamic-pituitary-adrenal (HPA) axis activity may be mediated by decreases in hippocampal neurotrophin expression.

KW - Adrenal glands

KW - BDNF

KW - Dorsal hippocampus

KW - Early-life stress

KW - NGF

KW - NT-3

KW - Time-dependent sensitization

KW - Ventral hippocampus

UR - https://www.scopus.com/pages/publications/33746458880

U2 - 10.1196/annals.1364.060

DO - 10.1196/annals.1364.060

M3 - Article

C2 - 16891615

AN - SCOPUS:33746458880

SN - 0077-8923

VL - 1071

SP - 542

EP - 546

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

ER -

Developmental trauma is associated with behavioral hyperarousal, altered HPA axis activity, and decreased hippocampal neurotrophin expression in the adult rat

Abstract

Keywords

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