TY - JOUR
T1 - Developmental stress elicits preference for methamphetamine in the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder
AU - Womersley, Jacqueline S.
AU - Mpeta, Bafokeng
AU - Dimatelis, Jacqueline J.
AU - Kellaway, Lauriston A.
AU - Stein, Dan J.
AU - Russell, Vivienne A.
N1 - Publisher Copyright:
© 2016 The Author(s).
PY - 2016/6/17
Y1 - 2016/6/17
N2 - Background: Developmental stress has been hypothesised to interact with genetic predisposition to increase the risk of developing substance use disorders. Here we have investigated the effects of maternal separation-induced developmental stress using a behavioural proxy of methamphetamine preference in an animal model of attention-deficit/hyperactivity disorder, the spontaneously hypertensive rat, versus Wistar Kyoto and Sprague-Dawley comparator strains. Results: Analysis of results obtained using a conditioned place preference paradigm revealed a significant strain × stress interaction with maternal separation inducing preference for the methamphetamine-associated compartment in spontaneously hypertensive rats. Maternal separation increased behavioural sensitization to the locomotor-stimulatory effects of methamphetamine in both spontaneously hypertensive and Sprague-Dawley strains but not in Wistar Kyoto rats. Conclusions: Our findings indicate that developmental stress in a genetic rat model of attention-deficit/hyperactivity disorder may foster a vulnerability to the development of substance use disorders.
AB - Background: Developmental stress has been hypothesised to interact with genetic predisposition to increase the risk of developing substance use disorders. Here we have investigated the effects of maternal separation-induced developmental stress using a behavioural proxy of methamphetamine preference in an animal model of attention-deficit/hyperactivity disorder, the spontaneously hypertensive rat, versus Wistar Kyoto and Sprague-Dawley comparator strains. Results: Analysis of results obtained using a conditioned place preference paradigm revealed a significant strain × stress interaction with maternal separation inducing preference for the methamphetamine-associated compartment in spontaneously hypertensive rats. Maternal separation increased behavioural sensitization to the locomotor-stimulatory effects of methamphetamine in both spontaneously hypertensive and Sprague-Dawley strains but not in Wistar Kyoto rats. Conclusions: Our findings indicate that developmental stress in a genetic rat model of attention-deficit/hyperactivity disorder may foster a vulnerability to the development of substance use disorders.
KW - Addiction
KW - Attention-deficit/hyperactivity disorder
KW - Conditioned place preference
KW - Developmental stress
KW - Methamphetamine
KW - Spontaneously hypertensive rat
UR - http://www.scopus.com/inward/record.url?scp=84975256330&partnerID=8YFLogxK
U2 - 10.1186/s12993-016-0102-3
DO - 10.1186/s12993-016-0102-3
M3 - Article
C2 - 27317355
AN - SCOPUS:84975256330
SN - 1744-9081
VL - 12
JO - Behavioral and Brain Functions
JF - Behavioral and Brain Functions
IS - 1
M1 - 18
ER -