Developmental expression of brain derived neurotrophic factor mRNA by neurons of fetal and adult monkey prefrontal cortex

G. W. Huntley; D. L. Benson; E. G. Jones; P. J. Isackson

doi:10.1016/0165-3806(92)90103-4

Developmental expression of brain derived neurotrophic factor mRNA by neurons of fetal and adult monkey prefrontal cortex

G. W. Huntley
, D. L. Benson
, E. G. Jones
, P. J. Isackson

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

In situ hybridization histochemistry with labeled cRNA probes complementary to monkey brain derived neurotrophic factor (BDNF) mRNAs has been used to study the cellular localization and expression of this neurotrophin in the prefrontal cerebral cortex of fetal and adult monkeys. Expression could not be detected in prefrontal cortex before the 121st fetal day. Thereafter, in fetal life and in adulthood BDNF mRNA could be detected primarily in large, putative pyramidal cells of layers III and VI throughout the prefrontal cortex. The temporal course and cellular localization of BDNF expression suggests its association with the development and stabilization of specific connections in regions of cortex that display marked functional plasticity.

Original language	English
Pages (from-to)	53-63
Number of pages	11
Journal	Developmental Brain Research
Volume	70
Issue number	1
DOIs	https://doi.org/10.1016/0165-3806(92)90103-4
State	Published - 20 Nov 1992
Externally published	Yes

Keywords

Cortical development
Gene expression
Growth factor
In situ hybridization
Primate

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10.1016/0165-3806(92)90103-4

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title = "Developmental expression of brain derived neurotrophic factor mRNA by neurons of fetal and adult monkey prefrontal cortex",

abstract = "In situ hybridization histochemistry with labeled cRNA probes complementary to monkey brain derived neurotrophic factor (BDNF) mRNAs has been used to study the cellular localization and expression of this neurotrophin in the prefrontal cerebral cortex of fetal and adult monkeys. Expression could not be detected in prefrontal cortex before the 121st fetal day. Thereafter, in fetal life and in adulthood BDNF mRNA could be detected primarily in large, putative pyramidal cells of layers III and VI throughout the prefrontal cortex. The temporal course and cellular localization of BDNF expression suggests its association with the development and stabilization of specific connections in regions of cortex that display marked functional plasticity.",

keywords = "Cortical development, Gene expression, Growth factor, In situ hybridization, Primate",

author = "Huntley, \{G. W.\} and Benson, \{D. L.\} and Jones, \{E. G.\} and Isackson, \{P. J.\}",

note = "Funding Information: MH4418 from the National Institutes of Health, and National Institute of Metal Health, United States Public Health Service.",

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T1 - Developmental expression of brain derived neurotrophic factor mRNA by neurons of fetal and adult monkey prefrontal cortex

AU - Huntley, G. W.

AU - Benson, D. L.

AU - Jones, E. G.

AU - Isackson, P. J.

N1 - Funding Information: MH4418 from the National Institutes of Health, and National Institute of Metal Health, United States Public Health Service.

PY - 1992/11/20

Y1 - 1992/11/20

N2 - In situ hybridization histochemistry with labeled cRNA probes complementary to monkey brain derived neurotrophic factor (BDNF) mRNAs has been used to study the cellular localization and expression of this neurotrophin in the prefrontal cerebral cortex of fetal and adult monkeys. Expression could not be detected in prefrontal cortex before the 121st fetal day. Thereafter, in fetal life and in adulthood BDNF mRNA could be detected primarily in large, putative pyramidal cells of layers III and VI throughout the prefrontal cortex. The temporal course and cellular localization of BDNF expression suggests its association with the development and stabilization of specific connections in regions of cortex that display marked functional plasticity.

AB - In situ hybridization histochemistry with labeled cRNA probes complementary to monkey brain derived neurotrophic factor (BDNF) mRNAs has been used to study the cellular localization and expression of this neurotrophin in the prefrontal cerebral cortex of fetal and adult monkeys. Expression could not be detected in prefrontal cortex before the 121st fetal day. Thereafter, in fetal life and in adulthood BDNF mRNA could be detected primarily in large, putative pyramidal cells of layers III and VI throughout the prefrontal cortex. The temporal course and cellular localization of BDNF expression suggests its association with the development and stabilization of specific connections in regions of cortex that display marked functional plasticity.

KW - Cortical development

KW - Gene expression

KW - Growth factor

KW - In situ hybridization

KW - Primate

UR - https://www.scopus.com/pages/publications/0026498160

U2 - 10.1016/0165-3806(92)90103-4

DO - 10.1016/0165-3806(92)90103-4

M3 - Article

C2 - 1473278

AN - SCOPUS:0026498160

SN - 0165-3806

VL - 70

SP - 53

EP - 63

JO - Developmental Brain Research

JF - Developmental Brain Research

IS - 1

ER -

Developmental expression of brain derived neurotrophic factor mRNA by neurons of fetal and adult monkey prefrontal cortex

Abstract

Keywords

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