Development: Sketch for a theory of Oct4

Ryan T. Wagner; Thomas P. Zwaka

doi:10.1016/j.cub.2013.10.003

Development: Sketch for a theory of Oct4

Ryan T. Wagner, Thomas P. Zwaka

Research output: Contribution to journal › Short survey › peer-review

2 Scopus citations

Abstract

How is it that Oct4, a transcription factor that controls pluripotency in stem cells, also controls lineage specification? A recent study investigating common Oct4 targets in vertebrate species indicates an evolutionarily conserved role in mediating cell adhesion. This finding may help decipher Oct4's versatility in governing stem cell behaviors.

Original language	English
Pages (from-to)	R1014-R1016
Journal	Current Biology
Volume	23
Issue number	22
DOIs	https://doi.org/10.1016/j.cub.2013.10.003
State	Published - 18 Nov 2013

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title = "Development: Sketch for a theory of Oct4",

abstract = "How is it that Oct4, a transcription factor that controls pluripotency in stem cells, also controls lineage specification? A recent study investigating common Oct4 targets in vertebrate species indicates an evolutionarily conserved role in mediating cell adhesion. This finding may help decipher Oct4's versatility in governing stem cell behaviors.",

author = "Wagner, {Ryan T.} and Zwaka, {Thomas P.}",

year = "2013",

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doi = "10.1016/j.cub.2013.10.003",

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T2 - Sketch for a theory of Oct4

AU - Wagner, Ryan T.

AU - Zwaka, Thomas P.

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N2 - How is it that Oct4, a transcription factor that controls pluripotency in stem cells, also controls lineage specification? A recent study investigating common Oct4 targets in vertebrate species indicates an evolutionarily conserved role in mediating cell adhesion. This finding may help decipher Oct4's versatility in governing stem cell behaviors.

AB - How is it that Oct4, a transcription factor that controls pluripotency in stem cells, also controls lineage specification? A recent study investigating common Oct4 targets in vertebrate species indicates an evolutionarily conserved role in mediating cell adhesion. This finding may help decipher Oct4's versatility in governing stem cell behaviors.

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U2 - 10.1016/j.cub.2013.10.003

DO - 10.1016/j.cub.2013.10.003

M3 - Short survey

C2 - 24262829

AN - SCOPUS:84889071568

SN - 0960-9822

VL - 23

SP - R1014-R1016

JO - Current Biology

JF - Current Biology

IS - 22

ER -

Development: Sketch for a theory of Oct4

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