Development of next generation hemagglutinin-based broadly protective influenza virus vaccines

Raffael Nachbagauer, Peter Palese

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations

Abstract

Influenza viruses are a severe threat to human health and current vaccines do not provide sufficient protection. The highly variable nature of influenza viruses has made the production of efficacious vaccines a challenge. In recent years, a multitude of novel, broadly reactive influenza virus vaccination approaches have been described. What has long seemed impossible could now become reality in the near future — a new generation of influenza virus vaccines that provides long-lasting and broad protection against seasonal as well as potentially pandemic influenza virus strains. This review will discuss new hemagglutinin-based vaccines and their current stage of development.

Original languageEnglish
Pages (from-to)51-57
Number of pages7
JournalCurrent Opinion in Immunology
Volume53
DOIs
StatePublished - Aug 2018

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