Development of CAR T-cell lymphoma in 2 of 10 patients effectively treated with piggyBac-modified CD19 CAR T cells

David C. Bishop; Leighton E. Clancy; Renee Simms; Jane Burgess; Geetha Mathew; Leili Moezzi; Janine A. Street; Gaurav Sutrave; Elissa Atkins; Helen M. McGuire; Brian S. Gloss; Koon Lee; Wei Jiang; Karen Maddock; Georgia McCaughan; Selmir Avdic; Vicki Antonenas; Tracey A. O'Brien; Peter J. Shaw; David O. Irving; David J. Gottlieb; Emily Blyth; Kenneth P. Micklethwaite

doi:10.1182/blood.2021010813

Development of CAR T-cell lymphoma in 2 of 10 patients effectively treated with piggyBac-modified CD19 CAR T cells

David C. Bishop, Leighton E. Clancy, Renee Simms, Jane Burgess, Geetha Mathew, Leili Moezzi, Janine A. Street, Gaurav Sutrave, Elissa Atkins, Helen M. McGuire, Brian S. Gloss, Koon Lee, Wei Jiang, Karen Maddock, Georgia McCaughan, Selmir Avdic, Vicki Antonenas, Tracey A. O'Brien, Peter J. Shaw, David O. IrvingDavid J. Gottlieb, Emily Blyth, Kenneth P. Micklethwaite

Research output: Contribution to journal › Letter › peer-review

135 Scopus citations

Original language	English
Pages (from-to)	1504-1509
Number of pages	6
Journal	Blood
Volume	138
Issue number	16
DOIs	https://doi.org/10.1182/blood.2021010813
State	Published - 21 Oct 2021
Externally published	Yes

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10.1182/blood.2021010813

Cite this

Bishop, D. C., Clancy, L. E., Simms, R., Burgess, J., Mathew, G., Moezzi, L., Street, J. A., Sutrave, G., Atkins, E., McGuire, H. M., Gloss, B. S., Lee, K., Jiang, W., Maddock, K., McCaughan, G., Avdic, S., Antonenas, V., O'Brien, T. A., Shaw, P. J., ... Micklethwaite, K. P. (2021). Development of CAR T-cell lymphoma in 2 of 10 patients effectively treated with piggyBac-modified CD19 CAR T cells. Blood, 138(16), 1504-1509. https://doi.org/10.1182/blood.2021010813

@article{d6a62ffc18904aa5ab062bb88f224104,

title = "Development of CAR T-cell lymphoma in 2 of 10 patients effectively treated with piggyBac-modified CD19 CAR T cells",

author = "Bishop, \{David C.\} and Clancy, \{Leighton E.\} and Renee Simms and Jane Burgess and Geetha Mathew and Leili Moezzi and Street, \{Janine A.\} and Gaurav Sutrave and Elissa Atkins and McGuire, \{Helen M.\} and Gloss, \{Brian S.\} and Koon Lee and Wei Jiang and Karen Maddock and Georgia McCaughan and Selmir Avdic and Vicki Antonenas and O'Brien, \{Tracey A.\} and Shaw, \{Peter J.\} and Irving, \{David O.\} and Gottlieb, \{David J.\} and Emily Blyth and Micklethwaite, \{Kenneth P.\}",

note = "Funding Information: This work was supported by the Priority-driven Collaborative Cancer Research Scheme and was also funded by the Cure Cancer Australia Foundation and Cancer Australia (grant 1047454), the National Health and Medical Research Council (grant 1102172), Cancer Council New South Wales (translational program grant \#TPG 19-01), and the Sydney West Translational Cancer Research Centre, which was funded by Cancer Institute NSW (15/TRC101). D.C.B. was supported by a Leukaemia Foundation of Australia Clinical Scholarship, and a Haematology Society of Australia and New Zealand New Investigator Scholarship. The Australian governments fund Australian Red Cross Lifeblood to provide blood, blood products, and services to the Australian community. Funding Information: Flow cytometry was performed at the Westmead Scientific Platforms, which were supported by the Westmead Research Hub, Cancer Institute NSW, the National Health and Medical Research Council, and the Ian Potter Foundation. ",

year = "2021",

month = oct,

day = "21",

doi = "10.1182/blood.2021010813",

language = "English",

volume = "138",

pages = "1504--1509",

journal = "Blood",

issn = "0006-4971",

publisher = "Elsevier B.V.",

number = "16",

}

Bishop, DC, Clancy, LE, Simms, R, Burgess, J, Mathew, G, Moezzi, L, Street, JA, Sutrave, G, Atkins, E, McGuire, HM, Gloss, BS, Lee, K, Jiang, W, Maddock, K, McCaughan, G, Avdic, S, Antonenas, V, O'Brien, TA, Shaw, PJ, Irving, DO, Gottlieb, DJ, Blyth, E & Micklethwaite, KP 2021, 'Development of CAR T-cell lymphoma in 2 of 10 patients effectively treated with piggyBac-modified CD19 CAR T cells', Blood, vol. 138, no. 16, pp. 1504-1509. https://doi.org/10.1182/blood.2021010813

TY - JOUR

T1 - Development of CAR T-cell lymphoma in 2 of 10 patients effectively treated with piggyBac-modified CD19 CAR T cells

AU - Bishop, David C.

AU - Clancy, Leighton E.

AU - Simms, Renee

AU - Burgess, Jane

AU - Mathew, Geetha

AU - Moezzi, Leili

AU - Street, Janine A.

AU - Sutrave, Gaurav

AU - Atkins, Elissa

AU - McGuire, Helen M.

AU - Gloss, Brian S.

AU - Lee, Koon

AU - Jiang, Wei

AU - Maddock, Karen

AU - McCaughan, Georgia

AU - Avdic, Selmir

AU - Antonenas, Vicki

AU - O'Brien, Tracey A.

AU - Shaw, Peter J.

AU - Irving, David O.

AU - Gottlieb, David J.

AU - Blyth, Emily

AU - Micklethwaite, Kenneth P.

N1 - Funding Information: This work was supported by the Priority-driven Collaborative Cancer Research Scheme and was also funded by the Cure Cancer Australia Foundation and Cancer Australia (grant 1047454), the National Health and Medical Research Council (grant 1102172), Cancer Council New South Wales (translational program grant #TPG 19-01), and the Sydney West Translational Cancer Research Centre, which was funded by Cancer Institute NSW (15/TRC101). D.C.B. was supported by a Leukaemia Foundation of Australia Clinical Scholarship, and a Haematology Society of Australia and New Zealand New Investigator Scholarship. The Australian governments fund Australian Red Cross Lifeblood to provide blood, blood products, and services to the Australian community. Funding Information: Flow cytometry was performed at the Westmead Scientific Platforms, which were supported by the Westmead Research Hub, Cancer Institute NSW, the National Health and Medical Research Council, and the Ian Potter Foundation.

PY - 2021/10/21

Y1 - 2021/10/21

UR - https://www.scopus.com/pages/publications/85114342758

U2 - 10.1182/blood.2021010813

DO - 10.1182/blood.2021010813

M3 - Letter

C2 - 34010392

AN - SCOPUS:85114342758

SN - 0006-4971

VL - 138

SP - 1504

EP - 1509

JO - Blood

JF - Blood

IS - 16

ER -