Development of an international, multidisciplinary, patient-centered Standard Outcome Set for Multiple Sclerosis: The S.O.S.MS project

(S.O.S.MS Consensus Group)

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: Currently, outcomes of Multiple Sclerosis (MS) are not standardized and it is unclear which outcomes matter most to people living with MS. A consensus between patients and healthcare professionals on which outcomes to measure and how, would facilitate a move towards value-based MS care. Objective: to develop an internationally accepted, patient-relevant Standard Outcome Set for MS (S.O.S.MS). Methods: A mixed-method design was used, including a systematic literature review, four patient focus groups (n=30) and a RAND-modified Delphi process with seventeen MS experts of five disciplines from seven countries (the Netherlands, United States of America, Portugal, Ireland, India, New Zealand, Switzerland and Turkey). Results: A standard outcome set for MS was defined, consisting of fourteen outcomes divided in four domains: disease activity (n=3), symptoms (n=4), functional status (n=6), and quality of life (n=1). For each outcome, an outcome measure was selected and the measurement protocol was defined. In addition, seven case-mix variables were selected. Conclusion: This standard outcome set provides a guideline for measuring outcomes of MS in clinical practice and research. Using this set to monitor and (inter)nationally benchmark real-world outcomes of MS can support improvement of patient value and ultimately guide the transition towards value-based MS care.

Original languageEnglish
Article number104461
JournalMultiple Sclerosis and Related Disorders
Volume69
DOIs
StatePublished - Jan 2023
Externally publishedYes

Keywords

  • Benchmark
  • Core outcomes
  • Multiple sclerosis
  • Outcome indicator
  • Outcome set
  • PROM
  • Patient-reported outcomes
  • Value-based healthcare

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