@article{36c63680f6fd4ed09074abb635e3b96a,
title = "Development of a S-adenosylmethionine analog that intrudes the RNA-cap binding site of Zika methyltransferase",
abstract = "The Zika virus (ZIKV) has emerged as a major health hazard. We present here a high resolution structure (1.55 {\AA}) of ZIKV NS5 methyltransferase bound to a novel S-adenosylmethionine (SAM) analog in which a 4-fluorophenyl moiety substitutes for the methyl group. We show that the 4-fluorophenyl moiety extends into a portion of the RNA binding tunnel that typically contains the adenosine 2′OH of the RNA-cap moiety. Together, the new SAM analog and the high-resolution crystal structure are a step towards the development of antivirals against ZIKV and other flaviviruses.",
author = "Rinku Jain and Butler, {Kyle V.} and Javier Coloma and Jian Jin and Aggarwal, {Aneel K.}",
note = "Funding Information: At GM/CA@APS beamline 23ID-D (APS) at the Argonne National Laboratory for facilitating data collection. GM/CA@APS has been funded in whole or in part with Federal funds from the National Cancer Institute (ACB-12002) and the National Institute of General Medical Sciences (AGM-12006). This research used resources of the Advanced Photon Source, a U.S. Department of Energy (DOE) Office of Science User Facility operated for the DOE Office of Science by Argonne National Laboratory under Contract No. DE-AC02-06CH11357. This research was also supported in part by grants R01GM103893 and R01GM122749 (to J.J.) from the U.S. National Institutes of Health. Publisher Copyright: {\textcopyright} 2017 The Author(s).",
year = "2017",
month = dec,
day = "1",
doi = "10.1038/s41598-017-01756-7",
language = "English",
volume = "7",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",
}