Development of a Risk Prediction Score for Occult Cancer in Patients With VTE

Luis Jara-Palomares; Remedios Otero; David Jimenez; Marc Carrier; Inna Tzoran; Benjamin Brenner; Mireia Margeli; Juan Manuel Praena-Fernandez; Elvira Grandone; Manuel Monreal; Hervè Decousus; P. Prandoni; Raquel Barba; Pierpaolo Di Micco; Laurent Bertoletti; Abilio Reis; Marijan Bosevski; Henri Bounameaux; Radovan Malý; Philip Wells; Manolis Papadakis; M. A. Aibar; M. Alfonso; M. I. Asensio-Cruz; T. Auguet; J. I. Arcelus; M. Barrón; B. Barrón-Andrés; J. Bascuñana; A. Blanco-Molina; T. Bueso; I. Cañas; A. Ceausu; N. Chic; A. Culla; R. del Pozo; J. del Toro; M. C. Díaz-Pedroche; J. A. Díaz-Peromingo; M. Duffort; T. Elias-Hernández; C. Falgá; C. Fernández-Aracil; C. Fernández-Capitán; M. A. Fidalgo; C. Font; L. Font; P. Gallego; M. A. García; F. García-Bragado; M. García-Rodenas; V. Gómez; J. González; E. Grau; A. Grimón; R. Guijarro; L. Guirado; J. Gutiérrez; G. Hernández-Comes; L. Hernández-Blasco; E. Hernando-López; M. J. Jaras; D. Jiménez; M. D. Joya; P. Llamas; R. Lecumberri; J. L. Lobo; L. López-Jiménez; R. López-Reyes; J. B. López-Sáez; M. A. Lorente; A. Lorenzo; A. Maestre; P. J. Marchena; M. Martín; F. Martín-Martos; J. A. Nieto; S. Nieto; A. Núñez; M. J. Núñez; M. Odriozola; S. Otalora; A. Ovejero; J. M. Pedrajas; G. Pérez; C. Pérez-Ductor; M. L. Peris; J. A. Porras; O. Reig; A. Riera-Mestre; D. Riesco; A. Rivas; M. A. Rodríguez-Dávila; V. Rosa; P. Ruiz-Artacho; N. Ruiz-Giménez; J. C. Sahuquillo; M. C. Sala-Sainz; A. Sampériz; R. Sánchez; O. Sanz; S. Soler; B. Sopeña; J. M. Suriñach; C. Tolosa; J. Trujillo-Santos; F. Uresandi; B. Valero; R. Valle; J. Vela; P. Vicente; G. Vidal; A. Villalobos; J. Villalta; T. Vanassche; P. Verhamme; J. Hirmerova; E. Salgado; A. Bura-Riviere; D. Farge-Bancel; A. Hij; I. Mahé; A. Merah; F. Moustafa; A. Braester; G. Antonucci; G. Barillari; A. Bertone; F. Bilora; C. Bortoluzzi; M. Ciammaichella; C. Di Girolamo; R. Duce; P. Ferrazzi; M. Giorgi-Pierfranceschi; C. Lodigiani; R. Maida; D. Mastroiacovo; F. Pace; R. Pesavento; M. Pinelli; R. Poggio; L. Rota; E. Tiraferri; D. Tonello; A. Tufano; A. Visonà; B. Zalunardo; E. Drucka; D. Kigitovica; A. Skride; M. S. Sousa; M. Zdraveska; L. Mazzolai

doi:10.1016/j.chest.2016.10.025

Development of a Risk Prediction Score for Occult Cancer in Patients With VTE

Luis Jara-Palomares, Remedios Otero, David Jimenez, Marc Carrier, Inna Tzoran, Benjamin Brenner, Mireia Margeli, Juan Manuel Praena-Fernandez, Elvira Grandone, Manuel Monreal, Hervè Decousus, P. Prandoni, Raquel Barba, Pierpaolo Di Micco, Laurent Bertoletti, Abilio Reis, Marijan Bosevski, Henri Bounameaux, Radovan Malý, Philip WellsManolis Papadakis, M. A. Aibar, M. Alfonso, M. I. Asensio-Cruz, T. Auguet, J. I. Arcelus, M. Barrón, B. Barrón-Andrés, J. Bascuñana, A. Blanco-Molina, T. Bueso, I. Cañas, A. Ceausu, N. Chic, A. Culla, R. del Pozo, J. del Toro, M. C. Díaz-Pedroche, J. A. Díaz-Peromingo, M. Duffort, T. Elias-Hernández, C. Falgá, C. Fernández-Aracil, C. Fernández-Capitán, M. A. Fidalgo, C. Font, L. Font, P. Gallego, M. A. García, F. García-Bragado, M. García-Rodenas, V. Gómez, J. González, E. Grau, A. Grimón, R. Guijarro, L. Guirado, J. Gutiérrez, G. Hernández-Comes, L. Hernández-Blasco, E. Hernando-López, M. J. Jaras, D. Jiménez, M. D. Joya, P. Llamas, R. Lecumberri, J. L. Lobo, L. López-Jiménez, R. López-Reyes, J. B. López-Sáez, M. A. Lorente, A. Lorenzo, A. Maestre, P. J. Marchena, M. Martín, F. Martín-Martos, J. A. Nieto, S. Nieto, A. Núñez, M. J. Núñez, M. Odriozola, S. Otalora, A. Ovejero, J. M. Pedrajas, G. Pérez, C. Pérez-Ductor, M. L. Peris, J. A. Porras, O. Reig, A. Riera-Mestre, D. Riesco, A. Rivas, M. A. Rodríguez-Dávila, V. Rosa, P. Ruiz-Artacho, N. Ruiz-Giménez, J. C. Sahuquillo, M. C. Sala-Sainz, A. Sampériz, R. Sánchez, O. Sanz, S. Soler, B. Sopeña, J. M. Suriñach, C. Tolosa, J. Trujillo-Santos, F. Uresandi, B. Valero, R. Valle, J. Vela, P. Vicente, G. Vidal, A. Villalobos, J. Villalta, T. Vanassche, P. Verhamme, J. Hirmerova, E. Salgado, A. Bura-Riviere, D. Farge-Bancel, A. Hij, I. Mahé, A. Merah, F. Moustafa, A. Braester, G. Antonucci, G. Barillari, A. Bertone, F. Bilora, C. Bortoluzzi, M. Ciammaichella, C. Di Girolamo, R. Duce, P. Ferrazzi, M. Giorgi-Pierfranceschi, C. Lodigiani, R. Maida, D. Mastroiacovo, F. Pace, R. Pesavento, M. Pinelli, R. Poggio, L. Rota, E. Tiraferri, D. Tonello, A. Tufano, A. Visonà, B. Zalunardo, E. Drucka, D. Kigitovica, A. Skride, M. S. Sousa, M. Zdraveska, L. Mazzolai

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

Background The benefits of a diagnostic workup for occult cancer in patients with VTE are controversial. Our aim was to provide and validate a risk score for occult cancer in patients with VTE. Methods We designed a nested case-control study in a cohort of patients with VTE included in the RIETE (Registro Informatizado Enfermedad TromboEmbólica) registry from 2001 to 2014. Cases included cancer detected beyond the first 30 days and up to 24 months after VTE. Control subjects were defined as patients with VTE with no cancer in the same period. Results Of 5,863 eligible patients, 444 (7.6%; 95% CI, 6.8%-8.2%) were diagnosed with occult cancer. On multivariable analysis, variables selected were male sex, age > 70 years, chronic lung disease, anemia, elevated platelet count, prior VTE, and recent surgery. We built a risk score assigning points to each variable. Internal validity was confirmed using bootstrap analysis. The proportion of patients with cancer who scored ≤ 2 points was 5.8% (241 of 4,150) and that proportion in those who scored ≥ 3 points was 12% (203 of 1,713). We also identified scores divided by sex and age subgroups. Conclusions This is the first risk score that has identified patients with VTE who are at increased risk for occult cancer. Our score needs to be externally validated.

Original language	English
Pages (from-to)	564-571
Number of pages	8
Journal	Chest
Volume	151
Issue number	3
DOIs	https://doi.org/10.1016/j.chest.2016.10.025
State	Published - 1 Mar 2017
Externally published	Yes

Keywords

neoplasm
pulmonary embolism
risk
screening
venous thromboembolism

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10.1016/j.chest.2016.10.025

Cite this

Jara-Palomares, L., Otero, R., Jimenez, D., Carrier, M., Tzoran, I., Brenner, B., Margeli, M., Praena-Fernandez, J. M., Grandone, E., Monreal, M., Decousus, H., Prandoni, P., Barba, R., Di Micco, P., Bertoletti, L., Reis, A., Bosevski, M., Bounameaux, H., Malý, R., ... Mazzolai, L. (2017). Development of a Risk Prediction Score for Occult Cancer in Patients With VTE. Chest, 151(3), 564-571. https://doi.org/10.1016/j.chest.2016.10.025

@article{3539f1fedba94a71a9a27c1b5963c39f,

title = "Development of a Risk Prediction Score for Occult Cancer in Patients With VTE",

abstract = "Background The benefits of a diagnostic workup for occult cancer in patients with VTE are controversial. Our aim was to provide and validate a risk score for occult cancer in patients with VTE. Methods We designed a nested case-control study in a cohort of patients with VTE included in the RIETE (Registro Informatizado Enfermedad TromboEmb{\'o}lica) registry from 2001 to 2014. Cases included cancer detected beyond the first 30 days and up to 24 months after VTE. Control subjects were defined as patients with VTE with no cancer in the same period. Results Of 5,863 eligible patients, 444 (7.6%; 95% CI, 6.8%-8.2%) were diagnosed with occult cancer. On multivariable analysis, variables selected were male sex, age > 70 years, chronic lung disease, anemia, elevated platelet count, prior VTE, and recent surgery. We built a risk score assigning points to each variable. Internal validity was confirmed using bootstrap analysis. The proportion of patients with cancer who scored ≤ 2 points was 5.8% (241 of 4,150) and that proportion in those who scored ≥ 3 points was 12% (203 of 1,713). We also identified scores divided by sex and age subgroups. Conclusions This is the first risk score that has identified patients with VTE who are at increased risk for occult cancer. Our score needs to be externally validated.",

keywords = "neoplasm, pulmonary embolism, risk, screening, venous thromboembolism",

author = "Luis Jara-Palomares and Remedios Otero and David Jimenez and Marc Carrier and Inna Tzoran and Benjamin Brenner and Mireia Margeli and Praena-Fernandez, {Juan Manuel} and Elvira Grandone and Manuel Monreal and Herv{\`e} Decousus and P. Prandoni and Raquel Barba and {Di Micco}, Pierpaolo and Laurent Bertoletti and Abilio Reis and Marijan Bosevski and Henri Bounameaux and Radovan Mal{\'y} and Philip Wells and Manolis Papadakis and Aibar, {M. A.} and M. Alfonso and Asensio-Cruz, {M. I.} and T. Auguet and Arcelus, {J. I.} and M. Barr{\'o}n and B. Barr{\'o}n-Andr{\'e}s and J. Bascu{\~n}ana and A. Blanco-Molina and T. Bueso and I. Ca{\~n}as and A. Ceausu and N. Chic and A. Culla and {del Pozo}, R. and {del Toro}, J. and D{\'i}az-Pedroche, {M. C.} and D{\'i}az-Peromingo, {J. A.} and M. Duffort and T. Elias-Hern{\'a}ndez and C. Falg{\'a} and C. Fern{\'a}ndez-Aracil and C. Fern{\'a}ndez-Capit{\'a}n and Fidalgo, {M. A.} and C. Font and L. Font and P. Gallego and Garc{\'i}a, {M. A.} and F. Garc{\'i}a-Bragado and M. Garc{\'i}a-Rodenas and V. G{\'o}mez and J. Gonz{\'a}lez and E. Grau and A. Grim{\'o}n and R. Guijarro and L. Guirado and J. Guti{\'e}rrez and G. Hern{\'a}ndez-Comes and L. Hern{\'a}ndez-Blasco and E. Hernando-L{\'o}pez and Jaras, {M. J.} and D. Jim{\'e}nez and Joya, {M. D.} and P. Llamas and R. Lecumberri and Lobo, {J. L.} and L. L{\'o}pez-Jim{\'e}nez and R. L{\'o}pez-Reyes and L{\'o}pez-S{\'a}ez, {J. B.} and Lorente, {M. A.} and A. Lorenzo and A. Maestre and Marchena, {P. J.} and M. Mart{\'i}n and F. Mart{\'i}n-Martos and Nieto, {J. A.} and S. Nieto and A. N{\'u}{\~n}ez and N{\'u}{\~n}ez, {M. J.} and M. Odriozola and S. Otalora and A. Ovejero and Pedrajas, {J. M.} and G. P{\'e}rez and C. P{\'e}rez-Ductor and Peris, {M. L.} and Porras, {J. A.} and O. Reig and A. Riera-Mestre and D. Riesco and A. Rivas and Rodr{\'i}guez-D{\'a}vila, {M. A.} and V. Rosa and P. Ruiz-Artacho and N. Ruiz-Gim{\'e}nez and Sahuquillo, {J. C.} and Sala-Sainz, {M. C.} and A. Samp{\'e}riz and R. S{\'a}nchez and O. Sanz and S. Soler and B. Sope{\~n}a and Suri{\~n}ach, {J. M.} and C. Tolosa and J. Trujillo-Santos and F. Uresandi and B. Valero and R. Valle and J. Vela and P. Vicente and G. Vidal and A. Villalobos and J. Villalta and T. Vanassche and P. Verhamme and J. Hirmerova and E. Salgado and A. Bura-Riviere and D. Farge-Bancel and A. Hij and I. Mah{\'e} and A. Merah and F. Moustafa and A. Braester and G. Antonucci and G. Barillari and A. Bertone and F. Bilora and C. Bortoluzzi and M. Ciammaichella and {Di Girolamo}, C. and R. Duce and P. Ferrazzi and M. Giorgi-Pierfranceschi and C. Lodigiani and R. Maida and D. Mastroiacovo and F. Pace and R. Pesavento and M. Pinelli and R. Poggio and L. Rota and E. Tiraferri and D. Tonello and A. Tufano and A. Vison{\`a} and B. Zalunardo and E. Drucka and D. Kigitovica and A. Skride and Sousa, {M. S.} and M. Zdraveska and L. Mazzolai",

note = "Publisher Copyright: {\textcopyright} 2016 American College of Chest Physicians",

year = "2017",

month = mar,

day = "1",

doi = "10.1016/j.chest.2016.10.025",

language = "English",

volume = "151",

pages = "564--571",

journal = "Chest",

issn = "0012-3692",

publisher = "American College of Chest Physicians",

number = "3",

}

Jara-Palomares, L, Otero, R, Jimenez, D, Carrier, M, Tzoran, I, Brenner, B, Margeli, M, Praena-Fernandez, JM, Grandone, E, Monreal, M, Decousus, H, Prandoni, P, Barba, R, Di Micco, P, Bertoletti, L, Reis, A, Bosevski, M, Bounameaux, H, Malý, R, Wells, P, Papadakis, M, Aibar, MA, Alfonso, M, Asensio-Cruz, MI, Auguet, T, Arcelus, JI, Barrón, M, Barrón-Andrés, B, Bascuñana, J, Blanco-Molina, A, Bueso, T, Cañas, I, Ceausu, A, Chic, N, Culla, A, del Pozo, R, del Toro, J, Díaz-Pedroche, MC, Díaz-Peromingo, JA, Duffort, M, Elias-Hernández, T, Falgá, C, Fernández-Aracil, C, Fernández-Capitán, C, Fidalgo, MA, Font, C, Font, L, Gallego, P, García, MA, García-Bragado, F, García-Rodenas, M, Gómez, V, González, J, Grau, E, Grimón, A, Guijarro, R, Guirado, L, Gutiérrez, J, Hernández-Comes, G, Hernández-Blasco, L, Hernando-López, E, Jaras, MJ, Jiménez, D, Joya, MD, Llamas, P, Lecumberri, R, Lobo, JL, López-Jiménez, L, López-Reyes, R, López-Sáez, JB, Lorente, MA, Lorenzo, A, Maestre, A, Marchena, PJ, Martín, M, Martín-Martos, F, Nieto, JA, Nieto, S, Núñez, A, Núñez, MJ, Odriozola, M, Otalora, S, Ovejero, A, Pedrajas, JM, Pérez, G, Pérez-Ductor, C, Peris, ML, Porras, JA, Reig, O, Riera-Mestre, A, Riesco, D, Rivas, A, Rodríguez-Dávila, MA, Rosa, V, Ruiz-Artacho, P, Ruiz-Giménez, N, Sahuquillo, JC, Sala-Sainz, MC, Sampériz, A, Sánchez, R, Sanz, O, Soler, S, Sopeña, B, Suriñach, JM, Tolosa, C, Trujillo-Santos, J, Uresandi, F, Valero, B, Valle, R, Vela, J, Vicente, P, Vidal, G, Villalobos, A, Villalta, J, Vanassche, T, Verhamme, P, Hirmerova, J, Salgado, E, Bura-Riviere, A, Farge-Bancel, D, Hij, A, Mahé, I, Merah, A, Moustafa, F, Braester, A, Antonucci, G, Barillari, G, Bertone, A, Bilora, F, Bortoluzzi, C, Ciammaichella, M, Di Girolamo, C, Duce, R, Ferrazzi, P, Giorgi-Pierfranceschi, M, Lodigiani, C, Maida, R, Mastroiacovo, D, Pace, F, Pesavento, R, Pinelli, M, Poggio, R, Rota, L, Tiraferri, E, Tonello, D, Tufano, A, Visonà, A, Zalunardo, B, Drucka, E, Kigitovica, D, Skride, A, Sousa, MS, Zdraveska, M & Mazzolai, L 2017, 'Development of a Risk Prediction Score for Occult Cancer in Patients With VTE', Chest, vol. 151, no. 3, pp. 564-571. https://doi.org/10.1016/j.chest.2016.10.025

TY - JOUR

T1 - Development of a Risk Prediction Score for Occult Cancer in Patients With VTE

AU - Jara-Palomares, Luis

AU - Otero, Remedios

AU - Jimenez, David

AU - Carrier, Marc

AU - Tzoran, Inna

AU - Brenner, Benjamin

AU - Margeli, Mireia

AU - Praena-Fernandez, Juan Manuel

AU - Grandone, Elvira

AU - Monreal, Manuel

AU - Decousus, Hervè

AU - Prandoni, P.

AU - Barba, Raquel

AU - Di Micco, Pierpaolo

AU - Bertoletti, Laurent

AU - Reis, Abilio

AU - Bosevski, Marijan

AU - Bounameaux, Henri

AU - Malý, Radovan

AU - Wells, Philip

AU - Papadakis, Manolis

AU - Aibar, M. A.

AU - Alfonso, M.

AU - Asensio-Cruz, M. I.

AU - Auguet, T.

AU - Arcelus, J. I.

AU - Barrón, M.

AU - Barrón-Andrés, B.

AU - Bascuñana, J.

AU - Blanco-Molina, A.

AU - Bueso, T.

AU - Cañas, I.

AU - Ceausu, A.

AU - Chic, N.

AU - Culla, A.

AU - del Pozo, R.

AU - del Toro, J.

AU - Díaz-Pedroche, M. C.

AU - Díaz-Peromingo, J. A.

AU - Duffort, M.

AU - Elias-Hernández, T.

AU - Falgá, C.

AU - Fernández-Aracil, C.

AU - Fernández-Capitán, C.

AU - Fidalgo, M. A.

AU - Font, C.

AU - Font, L.

AU - Gallego, P.

AU - García, M. A.

AU - García-Bragado, F.

AU - García-Rodenas, M.

AU - Gómez, V.

AU - González, J.

AU - Grau, E.

AU - Grimón, A.

AU - Guijarro, R.

AU - Guirado, L.

AU - Gutiérrez, J.

AU - Hernández-Comes, G.

AU - Hernández-Blasco, L.

AU - Hernando-López, E.

AU - Jaras, M. J.

AU - Jiménez, D.

AU - Joya, M. D.

AU - Llamas, P.

AU - Lecumberri, R.

AU - Lobo, J. L.

AU - López-Jiménez, L.

AU - López-Reyes, R.

AU - López-Sáez, J. B.

AU - Lorente, M. A.

AU - Lorenzo, A.

AU - Maestre, A.

AU - Marchena, P. J.

AU - Martín, M.

AU - Martín-Martos, F.

AU - Nieto, J. A.

AU - Nieto, S.

AU - Núñez, A.

AU - Núñez, M. J.

AU - Odriozola, M.

AU - Otalora, S.

AU - Ovejero, A.

AU - Pedrajas, J. M.

AU - Pérez, G.

AU - Pérez-Ductor, C.

AU - Peris, M. L.

AU - Porras, J. A.

AU - Reig, O.

AU - Riera-Mestre, A.

AU - Riesco, D.

AU - Rivas, A.

AU - Rodríguez-Dávila, M. A.

AU - Rosa, V.

AU - Ruiz-Artacho, P.

AU - Ruiz-Giménez, N.

AU - Sahuquillo, J. C.

AU - Sala-Sainz, M. C.

AU - Sampériz, A.

AU - Sánchez, R.

AU - Sanz, O.

AU - Soler, S.

AU - Sopeña, B.

AU - Suriñach, J. M.

AU - Tolosa, C.

AU - Trujillo-Santos, J.

AU - Uresandi, F.

AU - Valero, B.

AU - Valle, R.

AU - Vela, J.

AU - Vicente, P.

AU - Vidal, G.

AU - Villalobos, A.

AU - Villalta, J.

AU - Vanassche, T.

AU - Verhamme, P.

AU - Hirmerova, J.

AU - Salgado, E.

AU - Bura-Riviere, A.

AU - Farge-Bancel, D.

AU - Hij, A.

AU - Mahé, I.

AU - Merah, A.

AU - Moustafa, F.

AU - Braester, A.

AU - Antonucci, G.

AU - Barillari, G.

AU - Bertone, A.

AU - Bilora, F.

AU - Bortoluzzi, C.

AU - Ciammaichella, M.

AU - Di Girolamo, C.

AU - Duce, R.

AU - Ferrazzi, P.

AU - Giorgi-Pierfranceschi, M.

AU - Lodigiani, C.

AU - Maida, R.

AU - Mastroiacovo, D.

AU - Pace, F.

AU - Pesavento, R.

AU - Pinelli, M.

AU - Poggio, R.

AU - Rota, L.

AU - Tiraferri, E.

AU - Tonello, D.

AU - Tufano, A.

AU - Visonà, A.

AU - Zalunardo, B.

AU - Drucka, E.

AU - Kigitovica, D.

AU - Skride, A.

AU - Sousa, M. S.

AU - Zdraveska, M.

AU - Mazzolai, L.

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Background The benefits of a diagnostic workup for occult cancer in patients with VTE are controversial. Our aim was to provide and validate a risk score for occult cancer in patients with VTE. Methods We designed a nested case-control study in a cohort of patients with VTE included in the RIETE (Registro Informatizado Enfermedad TromboEmbólica) registry from 2001 to 2014. Cases included cancer detected beyond the first 30 days and up to 24 months after VTE. Control subjects were defined as patients with VTE with no cancer in the same period. Results Of 5,863 eligible patients, 444 (7.6%; 95% CI, 6.8%-8.2%) were diagnosed with occult cancer. On multivariable analysis, variables selected were male sex, age > 70 years, chronic lung disease, anemia, elevated platelet count, prior VTE, and recent surgery. We built a risk score assigning points to each variable. Internal validity was confirmed using bootstrap analysis. The proportion of patients with cancer who scored ≤ 2 points was 5.8% (241 of 4,150) and that proportion in those who scored ≥ 3 points was 12% (203 of 1,713). We also identified scores divided by sex and age subgroups. Conclusions This is the first risk score that has identified patients with VTE who are at increased risk for occult cancer. Our score needs to be externally validated.

AB - Background The benefits of a diagnostic workup for occult cancer in patients with VTE are controversial. Our aim was to provide and validate a risk score for occult cancer in patients with VTE. Methods We designed a nested case-control study in a cohort of patients with VTE included in the RIETE (Registro Informatizado Enfermedad TromboEmbólica) registry from 2001 to 2014. Cases included cancer detected beyond the first 30 days and up to 24 months after VTE. Control subjects were defined as patients with VTE with no cancer in the same period. Results Of 5,863 eligible patients, 444 (7.6%; 95% CI, 6.8%-8.2%) were diagnosed with occult cancer. On multivariable analysis, variables selected were male sex, age > 70 years, chronic lung disease, anemia, elevated platelet count, prior VTE, and recent surgery. We built a risk score assigning points to each variable. Internal validity was confirmed using bootstrap analysis. The proportion of patients with cancer who scored ≤ 2 points was 5.8% (241 of 4,150) and that proportion in those who scored ≥ 3 points was 12% (203 of 1,713). We also identified scores divided by sex and age subgroups. Conclusions This is the first risk score that has identified patients with VTE who are at increased risk for occult cancer. Our score needs to be externally validated.

KW - neoplasm

KW - pulmonary embolism

KW - risk

KW - screening

KW - venous thromboembolism

UR - http://www.scopus.com/inward/record.url?scp=85014572550&partnerID=8YFLogxK

U2 - 10.1016/j.chest.2016.10.025

DO - 10.1016/j.chest.2016.10.025

M3 - Article

C2 - 27815153

AN - SCOPUS:85014572550

SN - 0012-3692

VL - 151

SP - 564

EP - 571

JO - Chest

JF - Chest

IS - 3

ER -

Development of a Risk Prediction Score for Occult Cancer in Patients With VTE

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Keywords

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