Development of a method for the preparation of zirconium-89 radiolabelled chitosan nanoparticles as an application for leukocyte trafficking with positron emission tomography

M. Fairclough, B. Ellis, H. Boutin, A. K.P. Jones, A. McMahon, S. Alzabin, A. Gennari, C. Prenant

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Positron Emission Tomography is an attractive imaging modality for monitoring the migration of cells to pathological tissue. We evaluated a new method for radiolabelling leukocytes with zirconium-89 (89Zr) using chitosan nanoparticles (CN, Z-average size 343 ± 210 nm and zeta potential +46 ± 4 mV) as the carrier. We propose that cell uptake of 89Zr-loaded CN occurred in a two-step process; cell membrane interaction with 89Zr-loaded CN was followed by a slower cell internalisation step.

Original languageEnglish
Pages (from-to)7-12
Number of pages6
JournalApplied Radiation and Isotopes
Volume130
DOIs
StatePublished - Dec 2017
Externally publishedYes

Keywords

  • Chitosan
  • Inflammation imaging
  • Leukocyte trafficking
  • Nanoparticles
  • PET
  • Zr-89

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