Abstract
Positron Emission Tomography is an attractive imaging modality for monitoring the migration of cells to pathological tissue. We evaluated a new method for radiolabelling leukocytes with zirconium-89 (89Zr) using chitosan nanoparticles (CN, Z-average size 343 ± 210 nm and zeta potential +46 ± 4 mV) as the carrier. We propose that cell uptake of 89Zr-loaded CN occurred in a two-step process; cell membrane interaction with 89Zr-loaded CN was followed by a slower cell internalisation step.
Original language | English |
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Pages (from-to) | 7-12 |
Number of pages | 6 |
Journal | Applied Radiation and Isotopes |
Volume | 130 |
DOIs | |
State | Published - Dec 2017 |
Externally published | Yes |
Keywords
- Chitosan
- Inflammation imaging
- Leukocyte trafficking
- Nanoparticles
- PET
- Zr-89