@inbook{9abff6c7d38f49afabc38c5ebede61e1,
title = "Development and multiparametric evaluation of experimental atherosclerosis in rabbits",
abstract = "Several animal models have been developed to study atherosclerosis. Here we present a rabbit atherosclerosis model generated by surgical denudation of the aortic endothelium in combination with a high-fat and cholesterol-enriched diet. This model is characterized by the formation of vascular lesions that exhibit several hallmarks of human atherosclerosis. Due to the rabbit{\textquoteright}s relative large size, as compared to rodents, this model is suited for the imaging-guided evaluation of novel therapeutic strategies using clinical scanners. In this chapter, we present an extensive outline of the procedures to induce aortic atherosclerotic lesions in rabbits as well as methods to evaluate the disease, including noninvasive in vivo multiparametric imaging and histopathology.",
keywords = "Imaging model, New Zealand White rabbit, PET/MRI, Rabbit atherosclerosis model, Translational",
author = "Senders, \{Max L.\} and Lobatto, \{Mark E.\} and Raphael Soler and Olivier Lairez and Carlos P{\'e}rez-Medina and Claudia Calcagno and Fayad, \{Zahi A.\} and Mulder, \{Willem J.M.\} and Francois Fay",
note = "Publisher Copyright: {\textcopyright} Springer Science+Business Media, LLC, part of Springer Nature 2018.",
year = "2018",
doi = "10.1007/978-1-4939-8597-5\_30",
language = "English",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "385--400",
booktitle = "Methods in Molecular Biology",
}