@inbook{9abff6c7d38f49afabc38c5ebede61e1,
title = "Development and multiparametric evaluation of experimental atherosclerosis in rabbits",
abstract = "Several animal models have been developed to study atherosclerosis. Here we present a rabbit atherosclerosis model generated by surgical denudation of the aortic endothelium in combination with a high-fat and cholesterol-enriched diet. This model is characterized by the formation of vascular lesions that exhibit several hallmarks of human atherosclerosis. Due to the rabbit{\textquoteright}s relative large size, as compared to rodents, this model is suited for the imaging-guided evaluation of novel therapeutic strategies using clinical scanners. In this chapter, we present an extensive outline of the procedures to induce aortic atherosclerotic lesions in rabbits as well as methods to evaluate the disease, including noninvasive in vivo multiparametric imaging and histopathology.",
keywords = "Imaging model, New Zealand White rabbit, PET/MRI, Rabbit atherosclerosis model, Translational",
author = "Senders, {Max L.} and Lobatto, {Mark E.} and Raphael Soler and Olivier Lairez and Carlos P{\'e}rez-Medina and Claudia Calcagno and Fayad, {Zahi A.} and Mulder, {Willem J.M.} and Francois Fay",
note = "Funding Information: We would like to thank all the members of the large animal unit of the Center for Comparative Medicine and Surgery at the Icahn School of Medicine at Mount Sinai for their continual excellent technical support with this model. We also would like to thank Ren{\'e}-Paul Lafarie for the great pictures of the angioplasty procedure. Histology images presented here were performed at the Microscopy Core at Icahn School of Medicine at Mount Sinai. PET/MR imaging was performed at the TMII Imaging Core at Icahn School of Medicine at Mount Sinai. All experiments presented in this chapter were performed in accordance with protocols approved by the Radiation Safety Committee and the Institutional Animal Care and Use Committee of the Icahn School of Medicine at Mount Sinai and followed National Institutes of Health guidelines for animal welfare. Some of the artworks present in Fig. 1 are adapted from Servier Medical Art and used under a Creative Commons Attribution 3.0 Unported License.This research was supported by “De Drie Lichten” Foundation in The Netherlands (M.L.S.), the American Heart Association17PRE33660729 (M.L.S.), the National Heart, Lung, and Blood Institute (NHLBI), and the National Institutes of Health (NIH), as a Program of Excellence in Nanotechnology (PEN) Award, Contract #HHSN268201000045C, NIH/NIBIBR01 EB009638 (Z.A.F.), Harold S. Geneen Charitable Trust Award (Z.A.F.), R01 HL125703 (W.J.M.M.), NWO Vidi 91713324 (W.J.M.M.), and PSC-CUNY (F.F). Publisher Copyright: {\textcopyright} Springer Science+Business Media, LLC, part of Springer Nature 2018.",
year = "2018",
doi = "10.1007/978-1-4939-8597-5_30",
language = "English",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "385--400",
booktitle = "Methods in Molecular Biology",
}