Development and Function of Arterial and Cardiac Macrophages

Filip K. Swirski, Clinton S. Robbins, Matthias Nahrendorf

Research output: Contribution to journalReview articlepeer-review

60 Scopus citations

Abstract

Macrophages inhabit all major organs, and are capable of adapting their functions to meet the needs of their home tissues. The recent recognition that tissue macrophages derive from different sources, coupled with the notion that environmental cues and inflammatory stimuli can sculpt and agitate homeostasis, provides a frame of reference from which we can decipher the breadth and depth of macrophage activity. Here we discuss macrophages residing in the cardiovascular system, focusing particularly on their development and function in steady state and disease. Central to our discussion is the tension between macrophage ontogeny as a determinant of macrophage function, and the idea that tissues condition macrophage activities and supplant the influence of macrophage origins in favor of environmental demands.

Original languageEnglish
Pages (from-to)32-40
Number of pages9
JournalTrends in Immunology
Volume37
Issue number1
DOIs
StatePublished - 1 Jan 2016
Externally publishedYes

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