Detrusor hyperreflexia in multiple sclerosis: Alleviation by a combination of imipramine and propantheline, a clinico-laboratory study

J. M. Rabey; E. Z. Moriel; A. Farkas; M. Firstater; I. Vardi; M. Streifler

doi:10.1159/000115051

Detrusor hyperreflexia in multiple sclerosis: Alleviation by a combination of imipramine and propantheline, a clinico-laboratory study

J. M. Rabey, E. Z. Moriel, A. Farkas, M. Firstater, I. Vardi, M. Streifler

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

16 patients with multiple sclerosis, complaining of urgency, frequency and urge incontinence were studied urologically. They all suffered from detrusor hyperreflexia. We managed to improve this disturbance by lowering the parasympathetic tone and at the same time increasing the sympathetic tone of the urinary outlet, using a combination of imipramine and propantheline. The subjective clinical alleviation was also corroborated by cystomanometry and urethral pressure profile before and after treatment.

Original language	English
Pages (from-to)	33-37
Number of pages	5
Journal	European Neurology
Volume	18
Issue number	1
DOIs	https://doi.org/10.1159/000115051
State	Published - 1979
Externally published	Yes

Keywords

Detrusor hyperreflexia
Imipramine
Multiple sclerosis
Propantheline

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title = "Detrusor hyperreflexia in multiple sclerosis: Alleviation by a combination of imipramine and propantheline, a clinico-laboratory study",

abstract = "16 patients with multiple sclerosis, complaining of urgency, frequency and urge incontinence were studied urologically. They all suffered from detrusor hyperreflexia. We managed to improve this disturbance by lowering the parasympathetic tone and at the same time increasing the sympathetic tone of the urinary outlet, using a combination of imipramine and propantheline. The subjective clinical alleviation was also corroborated by cystomanometry and urethral pressure profile before and after treatment.",

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year = "1979",

doi = "10.1159/000115051",

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T2 - Alleviation by a combination of imipramine and propantheline, a clinico-laboratory study

AU - Rabey, J. M.

AU - Moriel, E. Z.

AU - Farkas, A.

AU - Firstater, M.

AU - Vardi, I.

AU - Streifler, M.

PY - 1979

Y1 - 1979

N2 - 16 patients with multiple sclerosis, complaining of urgency, frequency and urge incontinence were studied urologically. They all suffered from detrusor hyperreflexia. We managed to improve this disturbance by lowering the parasympathetic tone and at the same time increasing the sympathetic tone of the urinary outlet, using a combination of imipramine and propantheline. The subjective clinical alleviation was also corroborated by cystomanometry and urethral pressure profile before and after treatment.

AB - 16 patients with multiple sclerosis, complaining of urgency, frequency and urge incontinence were studied urologically. They all suffered from detrusor hyperreflexia. We managed to improve this disturbance by lowering the parasympathetic tone and at the same time increasing the sympathetic tone of the urinary outlet, using a combination of imipramine and propantheline. The subjective clinical alleviation was also corroborated by cystomanometry and urethral pressure profile before and after treatment.

KW - Detrusor hyperreflexia

KW - Imipramine

KW - Multiple sclerosis

KW - Propantheline

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Detrusor hyperreflexia in multiple sclerosis: Alleviation by a combination of imipramine and propantheline, a clinico-laboratory study

Abstract

Keywords

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