Determination of vitamin b12 in infant formula and adult nutritionals by HPLC: First action 2011.10

Karen Schimpf, Renee Spiegel, Linda Thompson, Dawn Dowell

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

During the "Standards Development and International Harmonization: AOAC INTERNATIONAL Mid-Year Meeting" held on June 29, 2011, an Expert Review Panel (ERP) reviewed the method "Determination of Vitamin B 12 in Infant Formula and Adult Nutritionals by HPLC." Under the new pathway to Official MethodsSM, the ERP adopted the method as Official First Action. The method is applicable to the determination of vitamin B12 in infant formula and adult nutritionals. Data showed an average overall intermediate precision of 6.64% RSD, an estimated quantitation limit of 0.8 μg/kg, and a detection limit of 0.2 μg/kg in prepared samples. The standard range of the method is 2 to 200 μg/L, which corresponds to an analytical range of 0.8 to 500 μg/kg.

Original languageEnglish
Pages (from-to)313-318
Number of pages6
JournalJournal of AOAC International
Volume95
Issue number2
DOIs
StatePublished - 2012
Externally publishedYes

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