TY - JOUR
T1 - Determination of the solubility, dissolution enthalpy and entropy of Deflazacort in different solvents
AU - Wang, Peng
AU - Wang, Jingkang
AU - Gong, Junbo
AU - Zhang, Meijing
PY - 2011/7/25
Y1 - 2011/7/25
N2 - The solubility of Deflazacort in four solvents, acetone, ethyl acetate, ethanol and 2-propanol, was measured at temperatures ranging from 293.15. K to 348.15. K at atmospheric pressure using Laser Monitoring Technique. The solubility data were correlated by the modified Apelblat model. Then the dissolution enthalpy and entropy of Deflazacort were predicted from the solubility data using van't Hoff equation. In this study, it should be concluded that the viscosity and surface tension of solvents affect the solubility behavior, dissolution enthalpy and entropy of Deflazacort in different solvents.
AB - The solubility of Deflazacort in four solvents, acetone, ethyl acetate, ethanol and 2-propanol, was measured at temperatures ranging from 293.15. K to 348.15. K at atmospheric pressure using Laser Monitoring Technique. The solubility data were correlated by the modified Apelblat model. Then the dissolution enthalpy and entropy of Deflazacort were predicted from the solubility data using van't Hoff equation. In this study, it should be concluded that the viscosity and surface tension of solvents affect the solubility behavior, dissolution enthalpy and entropy of Deflazacort in different solvents.
KW - Deflazacort
KW - Dissolution enthalpy
KW - Dissolution entropy
KW - Solubility
UR - http://www.scopus.com/inward/record.url?scp=79957667066&partnerID=8YFLogxK
U2 - 10.1016/j.fluid.2011.03.032
DO - 10.1016/j.fluid.2011.03.032
M3 - Article
AN - SCOPUS:79957667066
SN - 0378-3812
VL - 306
SP - 171
EP - 174
JO - Fluid Phase Equilibria
JF - Fluid Phase Equilibria
IS - 2
ER -