Determination of protein structures - A series of fortunate events

Maksymilian Chruszcz; Alexander Wlodawer; Wladek Minor

doi:10.1529/biophysj.108.131789

Determination of protein structures - A series of fortunate events

Maksymilian Chruszcz
, Alexander Wlodawer
, Wladek Minor

Research output: Contribution to journal › Review article › peer-review

51 Scopus citations

Abstract

Determination of a macromolecular structure using x-ray diffraction is a multistep process that involves a plethora of techniques involving molecular biology, bioinformatics, and physical sciences. Counterintuitively, the success of any or all individual steps does not guarantee the success of the overall process. This review examines the difficulties presented by each step on the path from a gene to the final publication, together with certain lucky (or unlucky) circumstances that can affect the velocity along that path.

Original language	English
Pages (from-to)	1-9
Number of pages	9
Journal	Biophysical Journal
Volume	95
Issue number	1
DOIs	https://doi.org/10.1529/biophysj.108.131789
State	Published - 1 Jul 2008
Externally published	Yes

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10.1529/biophysj.108.131789

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author = "Maksymilian Chruszcz and Alexander Wlodawer and Wladek Minor",

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AU - Minor, Wladek

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AB - Determination of a macromolecular structure using x-ray diffraction is a multistep process that involves a plethora of techniques involving molecular biology, bioinformatics, and physical sciences. Counterintuitively, the success of any or all individual steps does not guarantee the success of the overall process. This review examines the difficulties presented by each step on the path from a gene to the final publication, together with certain lucky (or unlucky) circumstances that can affect the velocity along that path.

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Determination of protein structures - A series of fortunate events

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