Determination of influenza virus proteins required for genome replication

T. S. Huang, P. Palese, M. Krystal

Research output: Contribution to journalArticlepeer-review

186 Scopus citations


An artificial vaccinia virus vector-driven replication system for influenza virus RNA has been developed. In this system, a synthetic NS-like gene is replicated and expressed by influenza virus proteins supplied through infection with vaccinia virus recombinant vectors. The minimum subset of influenza virus proteins needed for specific replication and expression of the viral ribonucleoprotein was found to be the three polymerase proteins (PB1, PB2, and PA) and the nucleoprotein.

Original languageEnglish
Pages (from-to)5669-5673
Number of pages5
JournalJournal of Virology
Issue number11
StatePublished - 1990


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