Determination of anthocyanins in the urine of patients with colorectal liver metastases after administration of bilberry extract

Hong Cai, Sarah C. Thomasset, David P. Berry, Giuseppe Garcea, Karen Brown, William P. Steward, Andreas J. Gescher

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Anthocyanins possess cancer chemopreventive properties in preclinical models. Their clinical pharmacology is only poorly understood. In this pilot study, anthocyanins and their metabolites were analysed in the urine of two patients with colorectal liver metastases. They received a single dose of 1.88g standardized bilberry extract (mirtoselect) via either nasogastric or nasojejunal tube intra-operatively during liver resection. HPLC-MS/MS and HPLC-UV analysis showed there were more anthocyanins and metabolites in the urine of the patient who received mirtoselect via the stomach than via the jejunum. This result is consistent with information obtained in rodents which suggests the stomach is the predominant site for anthocyanin absorption.

Original languageEnglish
Pages (from-to)660-663
Number of pages4
JournalBiomedical Chromatography
Volume25
Issue number6
DOIs
StatePublished - Jun 2011
Externally publishedYes

Keywords

  • Adsorption
  • Anthocyanins
  • Human urine
  • Metabolites

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