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Detection of HTLV-III antibody in cerebrospinal fluid from patients with AIDS and pre-AIDS with the use of a commercial test system

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Abstract

Sixty-one paired sera and cerebrospinal fluid (CSF) specimens were tested for the presence of human T-cell lymphotropic virus/lymphadenopathy-associated virus (HTLV-III) antibodies. Of 16 sera negative for HTLV-III antibodies by enzyme-linked immunosorbent assay (ELISA), the corresponding CSF results were also negative. Forty-two of 45 (93%) CSF specimens tested (in which the corresponding sera were HTLV-III antibody positive) were positive by ELISA. Western blot analysis (WB) of 24 paired specimens, as well as retrospectively acquired case histories, confirmed the results obtained by ELISA.

Original languageEnglish
Pages (from-to)351-353
Number of pages3
JournalAmerican Journal of Clinical Pathology
Volume88
Issue number3
DOIs
StatePublished - 1987
Externally publishedYes

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