Detection of glutamate in the eye by Raman spectroscopy

A. Katz; Erik F. Kruger; Glenn Minko; C. H. Liu; Richard B. Rosen; R. R. Alfano

doi:10.1117/12.401625

Detection of glutamate in the eye by Raman spectroscopy

A. Katz
, Erik F. Kruger
, Glenn Minko
, C. H. Liu
, Richard B. Rosen
, R. R. Alfano

Research output: Contribution to journal › Conference article › peer-review

2 Scopus citations

Abstract

In this work, Raman spectroscopy was investigated as a tool for monitoring glutamate levels in the eye. Glutamate is a by product of nerve cell death, and is an indicator of macular degeneration. Raman spectra was from ex vivo porcine eyes was investigated, with glutamate injected into the eyes to simulate disease conditions. The Raman spectra from the native eye was dominated by the lens. However, an optical system was designed to optimize collection of signal from the vitreous and reduce the background lens signal. The molecular signature of glutamate was detectable in the Raman spectra by this system.

Original language	English
Pages (from-to)	169-171
Number of pages	3
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	4098
DOIs	https://doi.org/10.1117/12.401625
State	Published - 2000
Externally published	Yes
Event	Optical Devices and Diagnostics in Materials Science - San Diego, USA Duration: 1 Aug 2000 → 4 Aug 2000

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10.1117/12.401625

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title = "Detection of glutamate in the eye by Raman spectroscopy",

abstract = "In this work, Raman spectroscopy was investigated as a tool for monitoring glutamate levels in the eye. Glutamate is a by product of nerve cell death, and is an indicator of macular degeneration. Raman spectra was from ex vivo porcine eyes was investigated, with glutamate injected into the eyes to simulate disease conditions. The Raman spectra from the native eye was dominated by the lens. However, an optical system was designed to optimize collection of signal from the vitreous and reduce the background lens signal. The molecular signature of glutamate was detectable in the Raman spectra by this system.",

author = "A. Katz and Kruger, \{Erik F.\} and Glenn Minko and Liu, \{C. H.\} and Rosen, \{Richard B.\} and Alfano, \{R. R.\}",

year = "2000",

doi = "10.1117/12.401625",

language = "English",

volume = "4098",

pages = "169--171",

journal = "Proceedings of SPIE - The International Society for Optical Engineering",

issn = "0277-786X",

publisher = "SPIE",

note = "Optical Devices and Diagnostics in Materials Science ; Conference date: 01-08-2000 Through 04-08-2000",

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TY - JOUR

T1 - Detection of glutamate in the eye by Raman spectroscopy

AU - Katz, A.

AU - Kruger, Erik F.

AU - Minko, Glenn

AU - Liu, C. H.

AU - Rosen, Richard B.

AU - Alfano, R. R.

PY - 2000

Y1 - 2000

N2 - In this work, Raman spectroscopy was investigated as a tool for monitoring glutamate levels in the eye. Glutamate is a by product of nerve cell death, and is an indicator of macular degeneration. Raman spectra was from ex vivo porcine eyes was investigated, with glutamate injected into the eyes to simulate disease conditions. The Raman spectra from the native eye was dominated by the lens. However, an optical system was designed to optimize collection of signal from the vitreous and reduce the background lens signal. The molecular signature of glutamate was detectable in the Raman spectra by this system.

AB - In this work, Raman spectroscopy was investigated as a tool for monitoring glutamate levels in the eye. Glutamate is a by product of nerve cell death, and is an indicator of macular degeneration. Raman spectra was from ex vivo porcine eyes was investigated, with glutamate injected into the eyes to simulate disease conditions. The Raman spectra from the native eye was dominated by the lens. However, an optical system was designed to optimize collection of signal from the vitreous and reduce the background lens signal. The molecular signature of glutamate was detectable in the Raman spectra by this system.

UR - https://www.scopus.com/pages/publications/0033657736

U2 - 10.1117/12.401625

DO - 10.1117/12.401625

M3 - Conference article

AN - SCOPUS:0033657736

SN - 0277-786X

VL - 4098

SP - 169

EP - 171

JO - Proceedings of SPIE - The International Society for Optical Engineering

JF - Proceedings of SPIE - The International Society for Optical Engineering

T2 - Optical Devices and Diagnostics in Materials Science

Y2 - 1 August 2000 through 4 August 2000

ER -

Detection of glutamate in the eye by Raman spectroscopy

Abstract

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