Detection of a vita-PAMP STINGs cells into reticulophagy

Julien Moretti, J. Magarian Blander

Research output: Contribution to journalComment/debate

17 Scopus citations


Phagocytes cope with the threat of living bacteria via detection of vita-PAMPs, a specific class of pathogen-associated molecular patterns (PAMPs) that denotes microbial viability and trigger a commensurate innate response. Prokaryotic mRNA and cyclic-di-adenosine monophosphate (c-di-AMP) serve as vita-PAMPs for Gram-negative and Gram-positive bacteria, respectively, and elicit heightened proinflammatory responses not warranted for dead bacteria. The innate sensor TMEM173/STING detects c-di-AMP produced by internalized live Gram-positive bacteria, and quickly mobilizes interdependent pre-formed cell-autonomous responses including endoplasmic reticulum (ER) stress, MTOR inactivation, and reticulophagy. In turn, reticulophagy serves a dual role in restoring phagocyte homeostasis and orchestrating a type I IFN response. ER-stress induced macroautophagy/autophagy sequesters stressed ER, resolves ER stress and prevents apoptosis in response to live bacteria. Reticulophagy relocalizes ER-resident TMEM173/STING to phagophores, which then act as TMEM173/STING-signaling compartments. Here, we discuss our findings in the context of innate immunity and cell homeostasis.

Original languageEnglish
Pages (from-to)1102-1104
Number of pages3
Issue number6
StatePublished - 3 Jun 2018
Externally publishedYes


  • ER stress
  • ER-phagy
  • Gram-positive bacteria
  • MTOR
  • autophagy
  • c-di-AMP
  • cell-autonomous innate immunity
  • type-I interferon
  • vita-PAMP


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