Detection and characterization of influenza B virus with reduced neuraminidase susceptibility in a stem cell transplant recipient

Rosy Priya L. Kodiyanplakkal; Jennifer M. Laplante; Lars F. Westblade; Koen Van Besien; Mirella Salvatore; Kirsten St. George

doi:10.1093/ofid/ofz493

Detection and characterization of influenza B virus with reduced neuraminidase susceptibility in a stem cell transplant recipient

Rosy Priya L. Kodiyanplakkal, Jennifer M. Laplante, Lars F. Westblade, Koen Van Besien, Mirella Salvatore, Kirsten St. George

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Antiviral-resistant influenza viruses in the clinical environment, especially type B, are reported rarely. A stem cell transplant recipient remained influenza B positive for 2 months, despite repeated antiviral treatments. Laboratory tests demonstrated the evolution and persistence of neuraminidase inhibitor-resistant influenza B virus with a substitution at codon 119.

Original language	English
Journal	Open Forum Infectious Diseases
Volume	6
Issue number	12
DOIs	https://doi.org/10.1093/ofid/ofz493
State	Published - 1 Dec 2019
Externally published	Yes

Keywords

Antiviral resistance
Influenza B virus
Neuraminidase inhibitors
Neuraminidase mutation
Stem cell transplant

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10.1093/ofid/ofz493

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title = "Detection and characterization of influenza B virus with reduced neuraminidase susceptibility in a stem cell transplant recipient",

abstract = "Antiviral-resistant influenza viruses in the clinical environment, especially type B, are reported rarely. A stem cell transplant recipient remained influenza B positive for 2 months, despite repeated antiviral treatments. Laboratory tests demonstrated the evolution and persistence of neuraminidase inhibitor-resistant influenza B virus with a substitution at codon 119.",

keywords = "Antiviral resistance, Influenza B virus, Neuraminidase inhibitors, Neuraminidase mutation, Stem cell transplant",

author = "Kodiyanplakkal, {Rosy Priya L.} and Laplante, {Jennifer M.} and Westblade, {Lars F.} and {Van Besien}, Koen and Mirella Salvatore and {St. George}, Kirsten",

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AU - Westblade, Lars F.

AU - Van Besien, Koen

AU - Salvatore, Mirella

AU - St. George, Kirsten

N1 - Publisher Copyright: © The Author(s) 2019.

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Antiviral-resistant influenza viruses in the clinical environment, especially type B, are reported rarely. A stem cell transplant recipient remained influenza B positive for 2 months, despite repeated antiviral treatments. Laboratory tests demonstrated the evolution and persistence of neuraminidase inhibitor-resistant influenza B virus with a substitution at codon 119.

AB - Antiviral-resistant influenza viruses in the clinical environment, especially type B, are reported rarely. A stem cell transplant recipient remained influenza B positive for 2 months, despite repeated antiviral treatments. Laboratory tests demonstrated the evolution and persistence of neuraminidase inhibitor-resistant influenza B virus with a substitution at codon 119.

KW - Antiviral resistance

KW - Influenza B virus

KW - Neuraminidase inhibitors

KW - Neuraminidase mutation

KW - Stem cell transplant

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Detection and characterization of influenza B virus with reduced neuraminidase susceptibility in a stem cell transplant recipient

Abstract

Keywords

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