@article{369760d789a14383b52d46f270d54dac,
title = "Design of the ANal Cancer/HSIL Outcomes Research study (ANCHOR study): A randomized study to prevent anal cancer among persons living with HIV",
abstract = "It is well established that persons living with HIV (PLWH) have highly elevated rates of anal HSIL and anal cancer compared with those who are not living with HIV. The 5-year risk of anal cancer following anal HSIL has been reported to be as high as 14.1% among PLWH compared with 3.2% among those who are not living with HIV. To address these concerns, the AIDS Malignancy Consortium completed a large-scale, randomized trial to compare strategies for the prevention of anal cancer among PLWH with anal HSIL. The objective of the study was to determine whether treating anal HSIL was effective in reducing the incidence of anal cancer in PLWH compared with active monitoring. This paper describes the design of the ANal Cancer/HSIL Outcomes Research Study (ANCHOR) with respect to estimating the anal cancer event rate in this high risk population.",
keywords = "Anal cancer prevention, Clinical trial design, Persons living with HIV",
author = "{the ANCHOR Investigators} and Lee, {Jeannette Y.} and Lensing, {Shelly Y.} and Berry-Lawhorn, {J. Michael} and Naomi Jay and Darragh, {Teresa M.} and Goldstone, {Stephen E.} and Wilkin, {Timothy J.} and Stier, {Elizabeth A.} and Mark Einstein and Pugliese, {Julia C.} and Palefsky, {Joel M.}",
note = "Funding Information: ANCHOR National Coordinating Center: Joel Palefsky (principal investigator), Abigail Arons (national coordinator); ANCHOR Operations and Data Management Center (ODMC): Donald Vena (principal investigator), Julia Pugliese (ODMC coordinator); ANCHOR Statistical Center: Jeannette Y. Lee (principal investigator), Shelly Lensing (statistician). ANCHOR Clinical Sites (in alphabetical order): Anal Dysplasia Clinic Midwest: Gary Bucher (principal investigator), Karen Rottler (sub-investigator); Boston Medical Center: Elizabeth Stier (principal investigator), Irene Owusu Pokuaa (study coordinator); Capital Digestive Care: Jessica Korman (principal investigator); Shamekia Murray (study coordinator); DAP Health: Anthony Velasco (sub-investigator); Denver Public Health: Edward Gardner (principal investigator), Jeffrey Logan (sub-investigator); Dupont Circle Physicians Group: Ben Stearn (principal investigator), Joel Bromwell (study coordinator); Emory University: Lisa Flowers (principal investigator), Rachel Farah-Abraham (study coordinator); Harborview Medical Center: Jeffrey Schouten (sub-investigator); Laser Surgery Care Center: Stephen E. Goldstone (principal investigator), Jonathan Baker (sub-investigator); Louisiana State University: Michael Hagensee (principal investigator), Amber Trauth (study coordinator); Montefiore Medical Center: Rebecca Levine (principal investigator), Renee Huang (sub-investigator); Rutgers University New Jersey Medical School: Mark Einstein (principal investigator), Bernadette Cracchiolo (sub-investigator); University of California Los Angeles: Ronald Mitsuyasu (principal investigator), Nikkole Valdez (study coordinator); University of California San Francisco: Christina Brickman (principal investigator), Arezou Sadighi Akha (study coordinator); University of Colorado Denver: Hillary Dunlevy (principal investigator) Christine Conageski (sub-investigator); University of Miami: Isabella Rosa-Cunha (principal investigator), JoNell Potter (sub-investigator); University of Puerto Rico: Maribel Tirado (principal investigator), Christina C Munoz Masso (study coordinator); Virginia Mason Medical Center: David Aboulafia (principal investigator), Jeffrey Schouten (sub-investigator); Wake Forest Baptist Health: Luis F. Barroso (principal investigator), Elizabeth Zieser-Misenheimer (study coordinator); Weill Cornell Medical: Timothy Wilkin (principal investigator), Christina Megill (study coordinator). This work was supported by the National Cancer Institute of the National Institutes of Health (grant number UM1CA121947). The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Funding Information: This work was supported by the National Cancer Institute of the National Institutes of Health (grant number UM1CA121947 ). Publisher Copyright: {\textcopyright} 2022 The Authors",
year = "2022",
month = feb,
doi = "10.1016/j.cct.2022.106679",
language = "English",
volume = "113",
journal = "Contemporary Clinical Trials",
issn = "1551-7144",
publisher = "Elsevier Inc.",
}