Design and synthesis of a ratiometric fluorescent chemosensor for Cu(II) with a fluorophore hybridization approach

Zhipeng Liu; Changli Zhang; Xiaoqing Wang; Weijiang He; Zijian Guo

doi:10.1021/ol301849z

Design and synthesis of a ratiometric fluorescent chemosensor for Cu(II) with a fluorophore hybridization approach

Zhipeng Liu
, Changli Zhang
, Xiaoqing Wang
, Weijiang He
, Zijian Guo

Research output: Contribution to journal › Article › peer-review

140 Scopus citations

Abstract

A new ratiometric fluorescent sensor for Cu²⁺, WLN, has been developed via integrating a 1,8-naphthalimide fluorophore with 8-aminoquinoline. WLN exhibits a highly selective ratiometric response to Cu²⁺ over other transition metal ions in aqueous media. Moreover, its practical ratiometric imaging ability for intracellular Cu²⁺ has been confirmed in human breast adenocarcinoma cells (MCF-7 cells) using a confocal microscope.

Original language	English
Pages (from-to)	4378-4381
Number of pages	4
Journal	Organic Letters
Volume	14
Issue number	17
DOIs	https://doi.org/10.1021/ol301849z
State	Published - 7 Sep 2012
Externally published	Yes

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10.1021/ol301849z

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title = "Design and synthesis of a ratiometric fluorescent chemosensor for Cu(II) with a fluorophore hybridization approach",

abstract = "A new ratiometric fluorescent sensor for Cu2+, WLN, has been developed via integrating a 1,8-naphthalimide fluorophore with 8-aminoquinoline. WLN exhibits a highly selective ratiometric response to Cu2+ over other transition metal ions in aqueous media. Moreover, its practical ratiometric imaging ability for intracellular Cu2+ has been confirmed in human breast adenocarcinoma cells (MCF-7 cells) using a confocal microscope.",

author = "Zhipeng Liu and Changli Zhang and Xiaoqing Wang and Weijiang He and Zijian Guo",

year = "2012",

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journal = "Organic Letters",

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AU - Liu, Zhipeng

AU - Zhang, Changli

AU - Wang, Xiaoqing

AU - He, Weijiang

AU - Guo, Zijian

PY - 2012/9/7

Y1 - 2012/9/7

N2 - A new ratiometric fluorescent sensor for Cu2+, WLN, has been developed via integrating a 1,8-naphthalimide fluorophore with 8-aminoquinoline. WLN exhibits a highly selective ratiometric response to Cu2+ over other transition metal ions in aqueous media. Moreover, its practical ratiometric imaging ability for intracellular Cu2+ has been confirmed in human breast adenocarcinoma cells (MCF-7 cells) using a confocal microscope.

AB - A new ratiometric fluorescent sensor for Cu2+, WLN, has been developed via integrating a 1,8-naphthalimide fluorophore with 8-aminoquinoline. WLN exhibits a highly selective ratiometric response to Cu2+ over other transition metal ions in aqueous media. Moreover, its practical ratiometric imaging ability for intracellular Cu2+ has been confirmed in human breast adenocarcinoma cells (MCF-7 cells) using a confocal microscope.

UR - https://www.scopus.com/pages/publications/84866020854

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DO - 10.1021/ol301849z

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SP - 4378

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JO - Organic Letters

JF - Organic Letters

IS - 17

ER -

Design and synthesis of a ratiometric fluorescent chemosensor for Cu(II) with a fluorophore hybridization approach

Abstract

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