Design and analysis issues in gene and environment studies

Chen Yu Liu, Arnab Maity, Xihong Lin, Robert O. Wright, David C. Christiani

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Although some diseases are predominantly environmental or genetic, both environmental and genetic factors play an important role in most common or complex human diseases. One of the major challenges of exploring mechanisms and treatment of complex diseases is that neither purely environmental factors, nor purely genetic factors can fully explain the observed estimates of disease incidence and progression. To correctly model risk estimates, we must measure genetics and environment together in the same studies. Recent advances in human genomics have made it possible to study tens of thousands of genes simultaneously and incorporate their interactions with the environment. In this review, we discuss design and analysis issues for gene-environmental interactions studies.

Original languageEnglish
Title of host publicationEpigenetics and Pathology
Subtitle of host publicationExploring Connections between Genetic Mechanisms and Disease Expression
PublisherApple Academic Press
Number of pages32
ISBN (Electronic)9781482224825
ISBN (Print)9781926895789
StatePublished - 1 Jan 2013


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