Dermatological complications of diabetes mellitus; Allergy to insulin and oral agents

Long-standing diabetes and/or lack of tight glucose control over time may result in the development of complications affecting many organ systems including the skin. Due to the metabolic nature of the skin, fluctuations in glucose and insulin levels may result in skin changes. In many patients, the first presentation of diabetes may be in the form of skin changes. Therefore, recognition of skin manifestations of diabetes mellitus is an important aspect of the physical examination. Most cutaneous manifestations of diabetes are attributed either to chronic degenerative changes or to metabolic derangement.