TY - JOUR
T1 - Dermal sheath contraction powers stem cell niche relocation during hair cycle regression
AU - Heitman, Nicholas
AU - Sennett, Rachel
AU - Mok, Ka Wai
AU - Saxena, Nivedita
AU - Srivastava, Devika
AU - Martino, Pieter
AU - Grisanti, Laura
AU - Wang, Zichen
AU - Ma'ayan, Avi
AU - Rompolas, Panteleimon
AU - Rendl, Michael
N1 - Funding Information:
We thank V. Horsley, T. Tumbar, R. Paus, M. Rangl, and R. Krauss for invaluable discussions and comments on the manuscript. We are especially grateful to C. Jahoda for helpful discussions and launching dermal sheath research decades ago. Many thanks to D. Dubin and H. Khorasani for providing human scalp skin samples and to the personnel at ISMMS Flow Cytometry, Microscopy, Genomics, and Mouse Genetics CoREs for technical assistance. The ISMMS Microscopy CoRE was supported by NIH Shared Instrumentation grant IS10RR026639. N.H. and R.S. were supported by training grant T32GM007280 from NIH/NIGMS. N.H. was also supported by T32HHD075735 from NIH/NIDCR and F30AR070639 from NIH/NIAMS. D.S. and N.S. were supported by a fellowship of the Training Program in Stem Cell Research from the New York State Department of Health (NYSTEM-C32561GG). K.-W.M. was supported by The Science Appearance Career Development Award fellowship from the Dermatology Foundation. A.M. was supported by grants from NIH/OD (U54HL127624 and U24CA224260). P.R. was supported by an NIH/NEI grant (R01EY030599). M.R. was supported by grants from NIH/NIAMS (R01AR071047 and R01AR063151) and the New York State Department of Health (NYSTEM-C029574 and NYSTEM-C32561GG) and by a fellowship from the Irma T. Hirschl Trust.
Publisher Copyright:
© 2020 American Association for the Advancement of Science. All rights reserved.
PY - 2020/1/10
Y1 - 2020/1/10
N2 - Tissue homeostasis requires the balance of growth by cell production and regression through cell loss. In the hair cycle, during follicle regression, the niche traverses the skin through an unknown mechanism to reach the stem cell reservoir and trigger new growth. Here, we identify the dermal sheath that lines the follicle as the key driver of tissue regression and niche relocation through the smooth muscle contractile machinery that generates centripetal constriction force. We reveal that the calcium-calmodulin-myosin light chain kinase pathway controls sheath contraction. When this pathway is blocked, sheath contraction is inhibited, impeding follicle regression and niche relocation. Thus, our study identifies the dermal sheath as smooth muscle that drives follicle regression for reuniting niche and stem cells in order to regenerate tissue structure during homeostasis.
AB - Tissue homeostasis requires the balance of growth by cell production and regression through cell loss. In the hair cycle, during follicle regression, the niche traverses the skin through an unknown mechanism to reach the stem cell reservoir and trigger new growth. Here, we identify the dermal sheath that lines the follicle as the key driver of tissue regression and niche relocation through the smooth muscle contractile machinery that generates centripetal constriction force. We reveal that the calcium-calmodulin-myosin light chain kinase pathway controls sheath contraction. When this pathway is blocked, sheath contraction is inhibited, impeding follicle regression and niche relocation. Thus, our study identifies the dermal sheath as smooth muscle that drives follicle regression for reuniting niche and stem cells in order to regenerate tissue structure during homeostasis.
UR - http://www.scopus.com/inward/record.url?scp=85077761527&partnerID=8YFLogxK
U2 - 10.1126/science.aax9131
DO - 10.1126/science.aax9131
M3 - Article
C2 - 31857493
AN - SCOPUS:85077761527
SN - 0036-8075
VL - 367
SP - 161
EP - 166
JO - Science
JF - Science
IS - 6474
ER -