Dermal Condensate Niche Fate Specification Occurs Prior to Formation and Is Placode Progenitor Dependent

Ka Wai Mok; Nivedita Saxena; Nicholas Heitman; Laura Grisanti; Devika Srivastava; Mauro J. Muraro; Tina Jacob; Rachel Sennett; Zichen Wang; Yutao Su; Lu M. Yang; Avi Ma'ayan; David M. Ornitz; Maria Kasper; Michael Rendl

doi:10.1016/j.devcel.2018.11.034

Dermal Condensate Niche Fate Specification Occurs Prior to Formation and Is Placode Progenitor Dependent

Ka Wai Mok, Nivedita Saxena, Nicholas Heitman, Laura Grisanti, Devika Srivastava, Mauro J. Muraro, Tina Jacob, Rachel Sennett, Zichen Wang, Yutao Su, Lu M. Yang, Avi Ma'ayan, David M. Ornitz, Maria Kasper, Michael Rendl

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71 Scopus citations

Abstract

Mok et al. identify niche precursors during progenitor and niche formation in mouse embryonic hair follicles. Population-based and single-cell transcriptomics show that unclustered dermal condensate precursors are at a transitional fibroblast-to-DC state marked by successive waves of transcription factor and signaling molecule expression. Niche fate acquisition is not “pre-programmed” and requires placode progenitor-derived FGF20.

Original language	English
Pages (from-to)	32-48.e5
Journal	Developmental Cell
Volume	48
Issue number	1
DOIs	https://doi.org/10.1016/j.devcel.2018.11.034
State	Published - 7 Jan 2019

Keywords

cell fate specification
dermal condensate precursors
dermal papilla
hair follicle formation
hair follicle morphogenesis
placode progenitors
single cell
stem cell niche

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10.1016/j.devcel.2018.11.034

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Mok, K. W., Saxena, N., Heitman, N., Grisanti, L., Srivastava, D., Muraro, M. J., Jacob, T., Sennett, R., Wang, Z., Su, Y., Yang, L. M., Ma'ayan, A., Ornitz, D. M., Kasper, M., & Rendl, M. (2019). Dermal Condensate Niche Fate Specification Occurs Prior to Formation and Is Placode Progenitor Dependent. Developmental Cell, 48(1), 32-48.e5. https://doi.org/10.1016/j.devcel.2018.11.034

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title = "Dermal Condensate Niche Fate Specification Occurs Prior to Formation and Is Placode Progenitor Dependent",

abstract = "Mok et al. identify niche precursors during progenitor and niche formation in mouse embryonic hair follicles. Population-based and single-cell transcriptomics show that unclustered dermal condensate precursors are at a transitional fibroblast-to-DC state marked by successive waves of transcription factor and signaling molecule expression. Niche fate acquisition is not “pre-programmed” and requires placode progenitor-derived FGF20.",

keywords = "cell fate specification, dermal condensate precursors, dermal papilla, hair follicle formation, hair follicle morphogenesis, placode progenitors, single cell, stem cell niche",

author = "Mok, {Ka Wai} and Nivedita Saxena and Nicholas Heitman and Laura Grisanti and Devika Srivastava and Muraro, {Mauro J.} and Tina Jacob and Rachel Sennett and Zichen Wang and Yutao Su and Yang, {Lu M.} and Avi Ma'ayan and Ornitz, {David M.} and Maria Kasper and Michael Rendl",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2019",

month = jan,

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doi = "10.1016/j.devcel.2018.11.034",

language = "English",

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Mok, KW, Saxena, N, Heitman, N, Grisanti, L, Srivastava, D, Muraro, MJ, Jacob, T, Sennett, R, Wang, Z, Su, Y, Yang, LM, Ma'ayan, A, Ornitz, DM, Kasper, M & Rendl, M 2019, 'Dermal Condensate Niche Fate Specification Occurs Prior to Formation and Is Placode Progenitor Dependent', Developmental Cell, vol. 48, no. 1, pp. 32-48.e5. https://doi.org/10.1016/j.devcel.2018.11.034

TY - JOUR

T1 - Dermal Condensate Niche Fate Specification Occurs Prior to Formation and Is Placode Progenitor Dependent

AU - Mok, Ka Wai

AU - Saxena, Nivedita

AU - Heitman, Nicholas

AU - Grisanti, Laura

AU - Srivastava, Devika

AU - Muraro, Mauro J.

AU - Jacob, Tina

AU - Sennett, Rachel

AU - Wang, Zichen

AU - Su, Yutao

AU - Yang, Lu M.

AU - Ma'ayan, Avi

AU - Ornitz, David M.

AU - Kasper, Maria

AU - Rendl, Michael

PY - 2019/1/7

Y1 - 2019/1/7

N2 - Mok et al. identify niche precursors during progenitor and niche formation in mouse embryonic hair follicles. Population-based and single-cell transcriptomics show that unclustered dermal condensate precursors are at a transitional fibroblast-to-DC state marked by successive waves of transcription factor and signaling molecule expression. Niche fate acquisition is not “pre-programmed” and requires placode progenitor-derived FGF20.

AB - Mok et al. identify niche precursors during progenitor and niche formation in mouse embryonic hair follicles. Population-based and single-cell transcriptomics show that unclustered dermal condensate precursors are at a transitional fibroblast-to-DC state marked by successive waves of transcription factor and signaling molecule expression. Niche fate acquisition is not “pre-programmed” and requires placode progenitor-derived FGF20.

KW - cell fate specification

KW - dermal condensate precursors

KW - dermal papilla

KW - hair follicle formation

KW - hair follicle morphogenesis

KW - placode progenitors

KW - single cell

KW - stem cell niche

UR - http://www.scopus.com/inward/record.url?scp=85059551534&partnerID=8YFLogxK

U2 - 10.1016/j.devcel.2018.11.034

DO - 10.1016/j.devcel.2018.11.034

M3 - Article

C2 - 30595537

AN - SCOPUS:85059551534

SN - 1534-5807

VL - 48

SP - 32-48.e5

JO - Developmental Cell

JF - Developmental Cell

IS - 1

ER -

Dermal Condensate Niche Fate Specification Occurs Prior to Formation and Is Placode Progenitor Dependent

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Keywords

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