@article{3cee771a085848c1800af62dc9845115,
title = "Dermal Condensate Niche Fate Specification Occurs Prior to Formation and Is Placode Progenitor Dependent",
abstract = "Mok et al. identify niche precursors during progenitor and niche formation in mouse embryonic hair follicles. Population-based and single-cell transcriptomics show that unclustered dermal condensate precursors are at a transitional fibroblast-to-DC state marked by successive waves of transcription factor and signaling molecule expression. Niche fate acquisition is not “pre-programmed” and requires placode progenitor-derived FGF20.",
keywords = "cell fate specification, dermal condensate precursors, dermal papilla, hair follicle formation, hair follicle morphogenesis, placode progenitors, single cell, stem cell niche",
author = "Mok, {Ka Wai} and Nivedita Saxena and Nicholas Heitman and Laura Grisanti and Devika Srivastava and Muraro, {Mauro J.} and Tina Jacob and Rachel Sennett and Zichen Wang and Yutao Su and Yang, {Lu M.} and Avi Ma'ayan and Ornitz, {David M.} and Maria Kasper and Michael Rendl",
note = "Funding Information: We thank Elena Ezhkova (ISMMS) for sharing mice and reagents. Many thanks to the personnel at the ISMMS Flow Cytometry and Microscopy CoRE and to Venu Pothula for technical assistance with single-cell sorting. Thanks go to the personnel at the Genome Technology Center at NYU and to Judith Vivi{\'e} for single-cell RNA sequencing at the Hubrecht Institute (Netherlands). Additionally, we thank Marja Mikkola (U. Helsinki), Peggy Myung (Yale), and Martina Rangl (Cornell) for helpful discussions and valuable comments. K.-W.M was supported by The Science Appearance Career Development Award fellowship from the Dermatology Foundation . N.H. was supported by grants T32GM007280 from NIH/ NIGMS and F30AR070639 from NIH/NIAMS. A.M. was supported by NIH grants U54-HL127624 (LINCS-DCIC) and U24-CA224260 (IDG-KMC). D.M.O. was supported by NIH grant HL111190 and R21DC017042 . M.R. was supported by grants from NIH/NIAMS ( R01AR071047 ; R01AR063151 ) and New York State Department of Health (NYSTEM- C029574 ) and a fellowship from the Irma T. Hirschl Trust. Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",
year = "2019",
month = jan,
day = "7",
doi = "10.1016/j.devcel.2018.11.034",
language = "English",
volume = "48",
pages = "32--48.e5",
journal = "Developmental Cell",
issn = "1534-5807",
publisher = "Cell Press",
number = "1",
}