Abstract
The sodium salt of 7 cyanacetyl amino cephalosporanic acid (cephacetrile, C 36 278 Ba, Celospor), a new injectable cephalosporin antibiotic that is allegedly not nephrotoxic was evaluated in 15 subjects with varying degrees of renal functional impairment. Cephacetrile has a serum half life of 1.3 hr in normal subjects which depends on the glomerular filtration rate. The total plasma clearance rate and the renal clearance rate of cephacetrile are high compared with the clearance rates of other cephalosporins, so also is the fraction of the injected dose excreted in the urine. Renal excretion of cephacetrile is accomplished by glomerular filtration and tubular secretion in normal subjects, but in patients with renal failure there is little evidence of tubular secretion. Cephacetrile is partially dialyzable, but higher serum levels during hemodialysis are noted after a standard dose than are expected after a similar dose of cephalothin or cephaloridine.
| Translated title of the contribution | Effects of renal failure and hemodialysis on pharmacokinetics of cefacetrile |
|---|---|
| Original language | German |
| Pages (from-to) | 1470-1473 |
| Number of pages | 4 |
| Journal | Arzneimittel-Forschung/Drug Research |
| Volume | 24 |
| Issue number | 9 B |
| State | Published - 1974 |
| Externally published | Yes |