TY - JOUR
T1 - Depressive symptoms are associated with allostatic load among community-dwelling older adults
AU - Kobrosly, Roni W.
AU - van Wijngaarden, Edwin
AU - Seplaki, Christopher L.
AU - Cory-Slechta, Deborah A.
AU - Moynihan, Jan
N1 - Funding Information:
Dr. Seplaki is supported by Mentored Research Scientist Development Award number K01AG031332 from the National Institute on Aging . The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute on Aging or the National Institutes of Health.
Funding Information:
The project described was supported by Award Number UL1RR024160 from the National Center of Research Resources and 1R01AG025474 (Moynihan). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Center for Research Resources or the National Institutes of Health.
PY - 2014/1/17
Y1 - 2014/1/17
N2 - The allostatic load model has been used to quantify the physiological costs of the body's response to repeated stressful demands and may provide a useful, integrative perspective on the various correlates of late-life depressive symptoms. We interviewed 125 Rochester, NY adults, ranging in age from 67 to 94. years. We employed an allostatic load score as a measure of multisystem dysfunction in hypothalamic-pituitary-adrenal axis function, immune function, anabolic activity, and cardiovascular activity. Overall, affective, and somatic depressive symptom scores were computed using the 20-item Center for Epidemiologic Studies Depression Scale. Multiple linear regression models were used to estimate associations between allostatic load scores and affective, somatic, and overall depressive symptoms. Among our sample of mean age 76.1. years, the one-week prevalence of clinically significant depressive symptoms was 12.8%. In models adjusting for demographic, socioeconomic, and health-related factors, higher allostatic load scores were associated with elevated scores for overall, affective, and somatic depressive symptoms: beta. = 1.21 (95% CI. = 0.38, 2.05); beta. = 0.14 (95% CI. = 0.040, 0.24); beta. = 0.60 (95% CI. = 0.23, 0.97), respectively. Our results suggest that allostatic load measure is associated with late-life depressive symptoms. This association appears to be of clinical significance, as the magnitude of the effect size was comparable (but opposite in direction) to that of antidepressant use. Future research should examine the inter-relationships of allostatic load, psychological stress, and late-life depressive symptoms.
AB - The allostatic load model has been used to quantify the physiological costs of the body's response to repeated stressful demands and may provide a useful, integrative perspective on the various correlates of late-life depressive symptoms. We interviewed 125 Rochester, NY adults, ranging in age from 67 to 94. years. We employed an allostatic load score as a measure of multisystem dysfunction in hypothalamic-pituitary-adrenal axis function, immune function, anabolic activity, and cardiovascular activity. Overall, affective, and somatic depressive symptom scores were computed using the 20-item Center for Epidemiologic Studies Depression Scale. Multiple linear regression models were used to estimate associations between allostatic load scores and affective, somatic, and overall depressive symptoms. Among our sample of mean age 76.1. years, the one-week prevalence of clinically significant depressive symptoms was 12.8%. In models adjusting for demographic, socioeconomic, and health-related factors, higher allostatic load scores were associated with elevated scores for overall, affective, and somatic depressive symptoms: beta. = 1.21 (95% CI. = 0.38, 2.05); beta. = 0.14 (95% CI. = 0.040, 0.24); beta. = 0.60 (95% CI. = 0.23, 0.97), respectively. Our results suggest that allostatic load measure is associated with late-life depressive symptoms. This association appears to be of clinical significance, as the magnitude of the effect size was comparable (but opposite in direction) to that of antidepressant use. Future research should examine the inter-relationships of allostatic load, psychological stress, and late-life depressive symptoms.
KW - Allostatic load
KW - Depression
KW - HPA axis
UR - https://www.scopus.com/pages/publications/84888068274
U2 - 10.1016/j.physbeh.2013.10.014
DO - 10.1016/j.physbeh.2013.10.014
M3 - Article
C2 - 24432360
AN - SCOPUS:84888068274
SN - 0031-9384
VL - 123
SP - 223
EP - 230
JO - Physiology and Behavior
JF - Physiology and Behavior
ER -