Depression or anxiety and all-cause mortality in adults with atrial fibrillation - A cohort study in Swedish primary care

Per Wändell, Axel C. Carlsson, Danijela Gasevic, Lars Wahlström, Jan Sundquist, Kristina Sundquist

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Objective Our aim was to study depression and anxiety in atrial fibrillation (AF) patients as risk factors for all-cause mortality in a primary care setting.Methods The study population included adults (n = 12 283) of 45 years and older diagnosed with AF in 75 primary care centres in Sweden. The association between depression or anxiety and all-cause mortality was explored using Cox regression analysis, with hazard ratios (HRs) and 95% confidence intervals (95% CIs). Analyses were conducted in men and women, adjusted for age, educational level, marital status, neighborhood socio-economic status (SES), change of neighborhood status and anxiety or depression, respectively, and cardiovascular co-morbidities. As a secondary analysis, background factors and their association with depression or anxiety were explored.Results The risk of all-cause mortality was higher among men with depression compared to their counterparts without depression even after full adjustment (HR = 1.28, 95% CI 1.08-1.53). For anxiety among men and anxiety or depression among women with AF, no associations were found. Cerebrovascular disease was more common among depressed AF patients.Conclusions Increased awareness of the higher mortality among men with AF and subsequent depression is called for. We suggest a tight follow-up and treatment of both ailments in clinical practice.

Original languageEnglish
Pages (from-to)59-66
Number of pages8
JournalAnnals of Medicine
Issue number1-2
StatePublished - 8 Jan 2016
Externally publishedYes


  • Anticoagulants
  • anxiety
  • atrial fibrillation
  • co-morbidity
  • depression
  • follow-up
  • gender
  • mortality


Dive into the research topics of 'Depression or anxiety and all-cause mortality in adults with atrial fibrillation - A cohort study in Swedish primary care'. Together they form a unique fingerprint.

Cite this