Depression in schizophrenia: Methodological artifact or distinct feature of the illness?

Eran Chemerinski, Christopher Bowie, Hannah Anderson, Philip D. Harvey

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


In schizophrenia, there is a conceptual overlap between depressive and negative symptoms. This study examined the dimensional structure of depressive symptoms and their overlap with negative symptoms in a large sample of older medicated schizophrenia outpatients. Self-reported depression was obtained with the Beck Depression Inventory-II (BDI-II). Three components from this scale (i.e., dysphoria, psychosomatic and regret domains) showed excellent factorability and good consistency. However, adequate construct validity and correlates with outcomes were found for the dysphoria and regret domains, but not for the total score or the psychosomatic domain. Thus, the evaluation of domains within the BDI-II provides a more pure and clinically-relevant assessment of depressed mood in schizophrenia than the use of this scale as a whole.

Original languageEnglish
Pages (from-to)431-440
Number of pages10
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Issue number4
StatePublished - Nov 2008


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