Dengue Virus Immunity Increases Zika Virus-Induced Damage during Pregnancy

  • Julia A. Brown
  • , Gursewak Singh
  • , Joshua A. Acklin
  • , Silviana Lee
  • , James E. Duehr
  • , Anupa N. Chokola
  • , Justin J. Frere
  • , Kevin W. Hoffman
  • , Gregory A. Foster
  • , David Krysztof
  • , Richard Cadagan
  • , Adam R. Jacobs
  • , Susan L. Stramer
  • , Florian Krammer
  • , Adolfo García-Sastre
  • , Jean K. Lim

Research output: Contribution to journalArticlepeer-review

93 Scopus citations

Abstract

Dengue-specific antibodies can cross-react to Zika virus. Brown et al. demonstrate that dengue-specific antibodies can enhance Zika virus pathogenesis during pregnancy by increasing damage to the placenta. These findings suggest a possible mechanism for the recent increase in severe pregnancy outcomes after Zika virus infection in areas where dengue co-circulates.

Original languageEnglish
Pages (from-to)751-762.e5
JournalImmunity
Volume50
Issue number3
DOIs
StatePublished - 19 Mar 2019

Keywords

  • Zika virus
  • antibodies
  • antibody-dependent enhancement
  • dengue virus
  • flavivirus
  • pathogenesis
  • placenta
  • pregnancy
  • trophoblasts

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