@article{8ba331b223ae450ea3e65d5599863aae,
title = "Dengue Virus Immunity Increases Zika Virus-Induced Damage during Pregnancy",
abstract = "Dengue-specific antibodies can cross-react to Zika virus. Brown et al. demonstrate that dengue-specific antibodies can enhance Zika virus pathogenesis during pregnancy by increasing damage to the placenta. These findings suggest a possible mechanism for the recent increase in severe pregnancy outcomes after Zika virus infection in areas where dengue co-circulates.",
keywords = "Zika virus, antibodies, antibody-dependent enhancement, dengue virus, flavivirus, pathogenesis, placenta, pregnancy, trophoblasts",
author = "Brown, {Julia A.} and Gursewak Singh and Acklin, {Joshua A.} and Silviana Lee and Duehr, {James E.} and Chokola, {Anupa N.} and Frere, {Justin J.} and Hoffman, {Kevin W.} and Foster, {Gregory A.} and David Krysztof and Richard Cadagan and Jacobs, {Adam R.} and Stramer, {Susan L.} and Florian Krammer and Adolfo Garc{\'i}a-Sastre and Lim, {Jean K.}",
note = "Funding Information: We thank Drs. Matthew J. Evan and Marion Sourisseau for providing the RNA standards for ZIKV quantification, Dr. Christian Schindler for providing the original Stat2 −/− mice, and Dr. Domenico Tortorella for providing the NS3 antibody. We also thank David Sachs for assistance with R and Justin Taft for assistance with CellProfiler software. We are grateful to Drs. Dusan Bogunovic and Christopher J. Obara for invaluable evaluation of our manuscript. We thank Dr. Michael Donovan, Olha Fedoryshyn, Anastasiya Dzhun, and Josefa Lopez from the Biorepository and Pathology CoRE at the Mount Sinai Health System. Microscopy and image analysis were performed at the Microscopy CoRE at the Icahn School of Medicine at Mount Sinai. This work was supported by NIAID grants R21AI130299 , R21AI129486 , R21AI139593 , and R21AI127955 ; NIAID training grant T32AI007647 ; and a supplement to NIAID grant U19AI118610 . The following reagents were obtained through BEI Resources, NIAID, and NIH, as part of the WRCEVA program: Dengue Virus Type 4, PR 06-65-740, NR-49757; Dengue Virus Type 1, BC89/94, NR-3787. Zika virus strain PRVABC59 was obtained through ATCC (VR-1843). Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2019",
month = mar,
day = "19",
doi = "10.1016/j.immuni.2019.01.005",
language = "English",
volume = "50",
pages = "751--762.e5",
journal = "Immunity",
issn = "1074-7613",
publisher = "Cell Press",
number = "3",
}