Dengue Virus Immunity Increases Zika Virus-Induced Damage during Pregnancy

Julia A. Brown, Gursewak Singh, Joshua A. Acklin, Silviana Lee, James E. Duehr, Anupa N. Chokola, Justin J. Frere, Kevin W. Hoffman, Gregory A. Foster, David Krysztof, Richard Cadagan, Adam R. Jacobs, Susan L. Stramer, Florian Krammer, Adolfo García-Sastre, Jean K. Lim

Research output: Contribution to journalArticlepeer-review

82 Scopus citations


Dengue-specific antibodies can cross-react to Zika virus. Brown et al. demonstrate that dengue-specific antibodies can enhance Zika virus pathogenesis during pregnancy by increasing damage to the placenta. These findings suggest a possible mechanism for the recent increase in severe pregnancy outcomes after Zika virus infection in areas where dengue co-circulates.

Original languageEnglish
Pages (from-to)751-762.e5
Issue number3
StatePublished - 19 Mar 2019


  • Zika virus
  • antibodies
  • antibody-dependent enhancement
  • dengue virus
  • flavivirus
  • pathogenesis
  • placenta
  • pregnancy
  • trophoblasts


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