Dendritic cells during Epstein Barr virus infection

Christian Münz

Research output: Contribution to journalShort surveypeer-review

17 Scopus citations

Abstract

Epstein Barr virus (EBV) causes persistent infection in more than 90% of the human adult population and is associated with 2% of all tumors in humans. This γ-herpes virus infects primarily human B and epithelial cells, but it has been reported to be sensed by dendritic cells (DCs) during primary infection. These activated DCs are thought to contribute to innate restriction of EBV infection and initiate EBV-specific adaptive immune responses via cross-priming. The respective evidence and their potential importance for EBV-specific vaccine development will be discussed in this review. & copy ; 2014 Münz.

Original languageEnglish
Article number308
JournalFrontiers in Microbiology
Volume5
Issue numberJUN
DOIs
StatePublished - 2014
Externally publishedYes

Keywords

  • Conventional dendritic cells
  • Monocyte-derived dendritic cells
  • Natural killer cells
  • Plasmacytoid dendritic cells
  • T cells

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