Dendritic cells as immunogens for human CTL responses

Armin Bender; Mark Sapp; Mary Feldman; Anita Reddy; Robert Seder; Gerold Schuler; Ralph M. Steinman; Nina Bhardwaj

doi:10.1007/978-1-4757-9966-8_62

Dendritic cells as immunogens for human CTL responses

Armin Bender, Mark Sapp, Mary Feldman, Anita Reddy, Robert Seder, Gerold Schuler, Ralph M. Steinman, Nina Bhardwaj

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The cellular requirements for generating potent human CD8+ CTLs to influenza A virus in vitro have been defined. Furthermore, we have developed improved methods for generating large numbers of DCs from non-proliferating progenitors. These developments have enabled the design of new strategies to elicit CTLs in vivo. For example together with IL-12, antigen-pulsed DCs may be a useful approach for boosting CTL responses against infectious agents and malignancies. Our results also reopen the potential use of inactivated virus preparations as immunogens for CTL responses.

Original language	English
Pages (from-to)	383-387
Number of pages	5
Journal	Advances in Experimental Medicine and Biology
Volume	417
DOIs	https://doi.org/10.1007/978-1-4757-9966-8_62
State	Published - 1997
Externally published	Yes

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author = "Armin Bender and Mark Sapp and Mary Feldman and Anita Reddy and Robert Seder and Gerold Schuler and Steinman, {Ralph M.} and Nina Bhardwaj",

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AU - Bender, Armin

AU - Sapp, Mark

AU - Feldman, Mary

AU - Reddy, Anita

AU - Seder, Robert

AU - Schuler, Gerold

AU - Steinman, Ralph M.

AU - Bhardwaj, Nina

PY - 1997

Y1 - 1997

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AB - The cellular requirements for generating potent human CD8+ CTLs to influenza A virus in vitro have been defined. Furthermore, we have developed improved methods for generating large numbers of DCs from non-proliferating progenitors. These developments have enabled the design of new strategies to elicit CTLs in vivo. For example together with IL-12, antigen-pulsed DCs may be a useful approach for boosting CTL responses against infectious agents and malignancies. Our results also reopen the potential use of inactivated virus preparations as immunogens for CTL responses.

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U2 - 10.1007/978-1-4757-9966-8_62

DO - 10.1007/978-1-4757-9966-8_62

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VL - 417

SP - 383

EP - 387

JO - Advances in Experimental Medicine and Biology

JF - Advances in Experimental Medicine and Biology

ER -

Dendritic cells as immunogens for human CTL responses

Abstract

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