Dendritic cells as immunogens for human CTL responses

Armin Bender, Mark Sapp, Mary Feldman, Anita Reddy, Robert Seder, Gerold Schuler, Ralph M. Steinman, Nina Bhardwaj

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


The cellular requirements for generating potent human CD8+ CTLs to influenza A virus in vitro have been defined. Furthermore, we have developed improved methods for generating large numbers of DCs from non-proliferating progenitors. These developments have enabled the design of new strategies to elicit CTLs in vivo. For example together with IL-12, antigen-pulsed DCs may be a useful approach for boosting CTL responses against infectious agents and malignancies. Our results also reopen the potential use of inactivated virus preparations as immunogens for CTL responses.

Original languageEnglish
Pages (from-to)383-387
Number of pages5
JournalAdvances in Experimental Medicine and Biology
StatePublished - 1997
Externally publishedYes


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