Abstract
Dendritic cells are a relative rare population of specialized antigen presenting cells that are distributed through most lymphoid and non-lymphoid tissues and play a critical role in linking the innate and adaptive arms of the immune system. The liver contains a heterogeneous population of dendritic cells that may contribute to liver inflammation and fibrosis through a number of mechanisms. This review summarizes current knowledge on the development and characterization of liver dendritic cells and their potential impact on liver fibrosis. This article is part of a Special Issue entitled: Fibrosis: Translation of basic research to human disease.
Original language | English |
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Pages (from-to) | 998-1004 |
Number of pages | 7 |
Journal | Biochimica et Biophysica Acta - Molecular Basis of Disease |
Volume | 1832 |
Issue number | 7 |
DOIs | |
State | Published - Jul 2013 |
Keywords
- Dendritic cell
- Fibrosis progression
- Fibrosis regression
- Flt3 ligand
- Hepatic inflammation
- Liver fibrosis