Dendritic cells and liver fibrosis

Adeeb H. Rahman, Costica Aloman

Research output: Contribution to journalReview articlepeer-review

60 Scopus citations

Abstract

Dendritic cells are a relative rare population of specialized antigen presenting cells that are distributed through most lymphoid and non-lymphoid tissues and play a critical role in linking the innate and adaptive arms of the immune system. The liver contains a heterogeneous population of dendritic cells that may contribute to liver inflammation and fibrosis through a number of mechanisms. This review summarizes current knowledge on the development and characterization of liver dendritic cells and their potential impact on liver fibrosis. This article is part of a Special Issue entitled: Fibrosis: Translation of basic research to human disease.

Original languageEnglish
Pages (from-to)998-1004
Number of pages7
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1832
Issue number7
DOIs
StatePublished - Jul 2013

Keywords

  • Dendritic cell
  • Fibrosis progression
  • Fibrosis regression
  • Flt3 ligand
  • Hepatic inflammation
  • Liver fibrosis

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