Dendritic cells and humoral immunity in humans

Hideki Ueno; Nathalie Schmitt; A. Karolina Palucka; Jacques Banchereau

doi:10.1038/icb.2010.28

Dendritic cells and humoral immunity in humans

Hideki Ueno, Nathalie Schmitt, A. Karolina Palucka, Jacques Banchereau

Research output: Contribution to journal › Review article › peer-review

52 Scopus citations

Abstract

Dendritic cells (DCs) orchestrate the innate and adaptive immune systems to induce tolerance and immunity. DC plasticity and subsets are prominent determinants in the regulation of immune responses. Our recent studies suggest that humoral and cellular immunity is regulated by different myeloid DC subsets with distinct intrinsic properties in humans. Although antibody response is preferentially mediated by CD14 dermal DCs, cytotoxic T-cell response is preferentially mediated by Langerhans cells (LCs). Thus, mechanisms whereby DCs induce humoral and cellular immunity seem to be fundamentally distinct. In this review, we will focus on the role of DCs in the development of humoral immunity. We will also discuss the mechanisms whereby DCs induce CD4 T cells associated with aiding B-cell response, including T follicular helper (Tfh) cells, and why human LCs lack this ability.

Original language	English
Pages (from-to)	376-380
Number of pages	5
Journal	Immunology and Cell Biology
Volume	88
Issue number	4
DOIs	https://doi.org/10.1038/icb.2010.28
State	Published - May 2010
Externally published	Yes

Keywords

CD4+ T cells
Dendritic cells
Human
Langerhans cells
T follicular helper cells

Access to Document

10.1038/icb.2010.28

Cite this

@article{91429fe448244c41b890841ee0c7dea9,

title = "Dendritic cells and humoral immunity in humans",

abstract = "Dendritic cells (DCs) orchestrate the innate and adaptive immune systems to induce tolerance and immunity. DC plasticity and subsets are prominent determinants in the regulation of immune responses. Our recent studies suggest that humoral and cellular immunity is regulated by different myeloid DC subsets with distinct intrinsic properties in humans. Although antibody response is preferentially mediated by CD14 dermal DCs, cytotoxic T-cell response is preferentially mediated by Langerhans cells (LCs). Thus, mechanisms whereby DCs induce humoral and cellular immunity seem to be fundamentally distinct. In this review, we will focus on the role of DCs in the development of humoral immunity. We will also discuss the mechanisms whereby DCs induce CD4 T cells associated with aiding B-cell response, including T follicular helper (Tfh) cells, and why human LCs lack this ability.",

keywords = "CD4+ T cells, Dendritic cells, Human, Langerhans cells, T follicular helper cells",

author = "Hideki Ueno and Nathalie Schmitt and Palucka, {A. Karolina} and Jacques Banchereau",

year = "2010",

month = may,

doi = "10.1038/icb.2010.28",

language = "English",

volume = "88",

pages = "376--380",

journal = "Immunology and Cell Biology",

issn = "0818-9641",

publisher = "John Wiley & Sons Inc.",

number = "4",

}

TY - JOUR

T1 - Dendritic cells and humoral immunity in humans

AU - Ueno, Hideki

AU - Schmitt, Nathalie

AU - Palucka, A. Karolina

AU - Banchereau, Jacques

PY - 2010/5

Y1 - 2010/5

N2 - Dendritic cells (DCs) orchestrate the innate and adaptive immune systems to induce tolerance and immunity. DC plasticity and subsets are prominent determinants in the regulation of immune responses. Our recent studies suggest that humoral and cellular immunity is regulated by different myeloid DC subsets with distinct intrinsic properties in humans. Although antibody response is preferentially mediated by CD14 dermal DCs, cytotoxic T-cell response is preferentially mediated by Langerhans cells (LCs). Thus, mechanisms whereby DCs induce humoral and cellular immunity seem to be fundamentally distinct. In this review, we will focus on the role of DCs in the development of humoral immunity. We will also discuss the mechanisms whereby DCs induce CD4 T cells associated with aiding B-cell response, including T follicular helper (Tfh) cells, and why human LCs lack this ability.

AB - Dendritic cells (DCs) orchestrate the innate and adaptive immune systems to induce tolerance and immunity. DC plasticity and subsets are prominent determinants in the regulation of immune responses. Our recent studies suggest that humoral and cellular immunity is regulated by different myeloid DC subsets with distinct intrinsic properties in humans. Although antibody response is preferentially mediated by CD14 dermal DCs, cytotoxic T-cell response is preferentially mediated by Langerhans cells (LCs). Thus, mechanisms whereby DCs induce humoral and cellular immunity seem to be fundamentally distinct. In this review, we will focus on the role of DCs in the development of humoral immunity. We will also discuss the mechanisms whereby DCs induce CD4 T cells associated with aiding B-cell response, including T follicular helper (Tfh) cells, and why human LCs lack this ability.

KW - CD4+ T cells

KW - Dendritic cells

KW - Human

KW - Langerhans cells

KW - T follicular helper cells

UR - http://www.scopus.com/inward/record.url?scp=77952239266&partnerID=8YFLogxK

U2 - 10.1038/icb.2010.28

DO - 10.1038/icb.2010.28

M3 - Review article

C2 - 20309010

AN - SCOPUS:77952239266

SN - 0818-9641

VL - 88

SP - 376

EP - 380

JO - Immunology and Cell Biology

JF - Immunology and Cell Biology

IS - 4

ER -

Dendritic cells and humoral immunity in humans

Abstract

Keywords

Access to Document

Fingerprint

Cite this