Dendritic cells acquire antigen from apoptotic cells and induce class I- restricted CTLS

Matthew L. Albert, Birthe Sauter, Nina Bhardwaj

Research output: Contribution to journalArticlepeer-review

2065 Scopus citations

Abstract

CD8+ cytotoxic T lymphocytes (GTLs) mediate resistance to infectious agents and tumours. Classically, CTLs recognize antigens that are localized in the cytoplasm of target cells, processed and presented as peptide complexes with class I molecules of the major histocompatibility complex (MHC). However, there is evidence for an exogenous pathway whereby antigens that are not expected to gain access to the cytoplasm are presented on MHC class I molecules. The most dramatic example is the in vivo phenomenon of cross-priming: antigens from donor cells are acquired by bone-marrow-derived host antigen-presenting cells (APCs) and presented on MHC class I molecules. Two unanswered questions concern the identity of this bone-marrow-derived cell and how such antigens are acquired. Here we show that human dendritic cells, but not macrophages, efficiently present antigen derived from apoptotic cells, stimulating class I-restricted CD8+ CTLs. Our findings suggest a mechanism by which potent APCs acquire antigens from tumours, transplants, infected cells, or even self-tissue, for stimulation or tolerization of CTLs.

Original languageEnglish
Pages (from-to)86-89
Number of pages4
JournalNature
Volume392
Issue number6671
DOIs
StatePublished - 5 Mar 1998
Externally publishedYes

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