Dendritic cell vaccines

Sylvia Adams, Nina Bhardwaj, David W. O'Neill

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Dendritic cells (DCs) are professional antigen presenting cells (APCs) central to the induction and regulation of immunity. These specialized immune cells can efficiently acquire antigens in the periphery, process them and present them to cells of the adaptive immune system, inducing antigen-specific immunity. DC-based vaccination therapies against cancer are very promising, since DCs are the most powerful T cell activators. The first part of the following chapter discusses dendritic cell biology pertinent to the design of dendritic cell vaccines (Figure 1), the second part focuses on advances in therapeutic DC cancer vaccination (Figure 2).

Original languageEnglish
Title of host publicationGeneral Principles of Tumor Immunotherapy
Subtitle of host publicationBasic and Clinical Applications of Tumor Immunology
PublisherSpringer Netherlands
Pages251-274
Number of pages24
ISBN (Electronic)9781402060878
ISBN (Print)9781402060861
DOIs
StatePublished - 2008
Externally publishedYes

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