Dendritic cell maturation by innate lymphocytes: Coordinated stimulation of innate and adaptive immunity

Christian Münz, Ralph M. Steinman, Shin Ichiro Fujii

Research output: Contribution to journalReview articlepeer-review

352 Scopus citations

Abstract

Pathogen recognition by Toll-like receptors (TLRs) on dendritic cells (DCs) leads to DC maturation and the initiation of adaptive immunity. Recent studies have shown that innate lymphocytes-natural killer (NK), natural killer T (NKT), and γδT cells-also trigger DC maturation. This interaction in turn expands and activates innate lymphocytes and initiates adaptive T cell immunity. Here, we comment on the evidence that these pathways are TLR independent and have the potential to respond to infection, malignancy, and immunotherapy. JEM

Original languageEnglish
Pages (from-to)203-207
Number of pages5
JournalJournal of Experimental Medicine
Volume202
Issue number2
DOIs
StatePublished - 18 Jul 2005
Externally publishedYes

Fingerprint

Dive into the research topics of 'Dendritic cell maturation by innate lymphocytes: Coordinated stimulation of innate and adaptive immunity'. Together they form a unique fingerprint.

Cite this