TY - JOUR
T1 - Dendritic cell interactions with NK cells from different tissues
AU - Ferlazzo, Guido
AU - Münz, Christian
N1 - Funding Information:
Acknowledgements Research in our laboratories is supported by the Burroughs Wellcome Fund, the Starr Foundation, the National Cancer Institute (R01CA108609 and R01CA101741), the National Institute of Allergy and Infectious Diseases (RFP-NIH-NIAID-DAIDS-BAA-06-19), and the Foundation for the National Institutes of Health (Grand Challenges in Global Health) to C.M., and by Associazione Italiana Ricerca sul Cancro (AIRC), Ministero Italiano della Salute—Programma Straordinario Ricerca Oncologica, Fondazione Banco di Sicilia, and Regione Sicilia—Ricerca Sanitaria Regionale 2007, to G.F.
PY - 2009/5
Y1 - 2009/5
N2 - Introduction: In recent years, it has been realized that innate lymphocytes do not act in isolation but potentiate their efficiency by interacting with each other, resulting even in the regulation of adaptive immune response. One such cross-talk exists between dendritic cells (DCs) and natural killer (NK) cells. Here, we summarize recent studies on which subsets of these two innate immune components participate in this interaction, how it influences immune responses, and to which extent similar stimuli are integrated by DCs and NK cells during innate immunity. Conclusion: We suggest that this cross-talk should be harnessed by activating both of these innate leucocyte populations with new adjuvant formulations for immunotherapies.
AB - Introduction: In recent years, it has been realized that innate lymphocytes do not act in isolation but potentiate their efficiency by interacting with each other, resulting even in the regulation of adaptive immune response. One such cross-talk exists between dendritic cells (DCs) and natural killer (NK) cells. Here, we summarize recent studies on which subsets of these two innate immune components participate in this interaction, how it influences immune responses, and to which extent similar stimuli are integrated by DCs and NK cells during innate immunity. Conclusion: We suggest that this cross-talk should be harnessed by activating both of these innate leucocyte populations with new adjuvant formulations for immunotherapies.
KW - DC/NK cell cross-talk
KW - Interleukin-12
KW - Interleukin-15
KW - Myeloid dendritic cells
KW - Natural killer cell subsets
KW - Plasmacytoid dendritic cells
KW - Type I interferon
UR - https://www.scopus.com/pages/publications/67349234981
U2 - 10.1007/s10875-009-9283-y
DO - 10.1007/s10875-009-9283-y
M3 - Review article
C2 - 19280325
AN - SCOPUS:67349234981
SN - 0271-9142
VL - 29
SP - 265
EP - 273
JO - Journal of Clinical Immunology
JF - Journal of Clinical Immunology
IS - 3
ER -